Chinese herbal medicine Fuzheng Kang-Ai decoction sensitized the effect of gefitinib on inhibition of human lung cancer cells through inactivating PI3-K/Akt -mediated suppressing MUC1 expression

Li Longmei; Wang SuMei; Zheng Fang; Wu WanYin; Hann Swei Sunny

首页> 外文期刊>Journal of Ethnopharmacology: An Interdisciplinary Journal Devoted to Bioscientific Research on Indigenous Drugs >Chinese herbal medicine Fuzheng Kang-Ai decoction sensitized the effect of gefitinib on inhibition of human lung cancer cells through inactivating PI3-K/Akt -mediated suppressing MUC1 expression

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Chinese herbal medicine Fuzheng Kang-Ai decoction sensitized the effect of gefitinib on inhibition of human lung cancer cells through inactivating PI3-K/Akt -mediated suppressing MUC1 expression

机译：中药扶正康爱汤通过失活PI3-K / Akt介导的MUC1表达抑制作用来提高吉非替尼对人肺癌细胞的抑制作用

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Ethnopharmacological relevance: Chinese herbal medicine (CHM) Fuzheng Kang-Ai (FZKA for short) decoction has been used as adjuvant treatment strategies in lung cancer patients for decades. However, the molecular mechanism underlying the therapeutic potential especially in sensitizing the effect of EGFR-TKI gefitinib has not been well elucidated.

机译：民族药理学相关性：数十年来，中药复方抗癌汤（简称FZKA）已被用作肺癌患者的辅助治疗策略。但是，尚未很好地阐明潜在治疗的分子机制，尤其是在增强EGFR-TKI吉非替尼作用方面。

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来源
《Journal of Ethnopharmacology: An Interdisciplinary Journal Devoted to Bioscientific Research on Indigenous Drugs》 |2016年第null期|共12页
作者
Li Longmei; Wang SuMei; Zheng Fang; Wu WanYin; Hann Swei Sunny;
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正文语种 eng
中图分类药理学;
关键词
FZKA decoction; Gefitinib; NSCLC cells; Akt; P65; MUC1;

机译：FZKA汤;吉非替尼;NSCLC细胞;Akt;P65;MUC1;

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1. Chinese herbal medicine Fuzheng Kang-Ai decoction sensitized the effect of gefitinib on inhibition of human lung cancer cells through inactivating PI3-K/Akt -mediated suppressing MUC1 expression [J] . Li Longmei, Wang SuMei, Zheng Fang, Journal of Ethnopharmacology: An Interdisciplinary Journal Devoted to Bioscientific Research on Indigenous Drugs . 2016,第Null期

机译：中药扶正康爱汤通过失活PI3-K / Akt介导的MUC1表达抑制作用来提高吉非替尼对人肺癌细胞的抑制作用
2. Decoction of Chinese Herbal Medicine Fuzheng Kang-Ai Induces Lung Cancer Cell Apoptosis via STAT3/Bcl-2/Caspase-3 Pathway [J] . Sumei Wang, Shunqin Long, Shujing Xiao, Evidence-based complementary and alternative medicine: eCAM . 2018,第1期

机译：中药扶正康艾汤通过STAT3 / Bcl-2 / Caspase-3途径诱导肺癌细胞凋亡
3. Decoction of Chinese Herbal Medicine Fuzheng Kang-Ai Induces Lung Cancer Cell Apoptosis via STAT3/Bcl-2/Caspase-3 Pathway [J] . Sumei Wang, Shunqin Long, Shujing Xiao, Evidence-based complementary and alternative medicine: eCAM . 2018,第3期

机译：中药扶正康艾汤通过STAT3 / Bcl-2 / Caspase-3途径诱导肺癌细胞凋亡
4. Yu Ping Feng San, an Ancient Chinese Herbal Decoction, Reverses Cisplatin-Induced Multi-Drug Resistance in Lung Cancer Cells: Mechanistic Evaluation and Development of New Formula [D] . Lou, Jianshu 2018

机译：俞平风散，一种古老的中药汤剂，逆转顺铂诱导的肺癌细胞多药耐药性：新药的机械评价和开发
5. Chinese Herbal Medicine Fuzheng Kang-Ai Decoction Inhibited Lung Cancer Cell Growth through AMPKα-Mediated Induction and Interplay of IGFBP1 and FOXO3a [O] . Fang Zheng, Jingjing Wu, Xiong Li, 2016

机译：中药扶正康爱汤通过AMPKα介导的IGFBP1和FOXO3a的相互作用及其相互作用抑制肺癌细胞的生长
6. Inactivation of PI3-K/Akt and reduction of SP1 and p65 expression increase the effect of solamargine on suppressing EP4 expression in human lung cancer cells [O] . YuQing Chen, Qing Tang, JingJing Wu, 2015

机译：PI3-K / Akt的失活以及SP1和p65表达的降低增强了索拉马汀抑制人肺癌细胞EP4表达的作用

Chinese herbal medicine Fuzheng Kang-Ai decoction sensitized the effect of gefitinib on inhibition of human lung cancer cells through inactivating PI3-K/Akt -mediated suppressing MUC1 expression

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