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首页> 外文期刊>Clinical EEG and neuroscience: official journal of the EEG and Clinical Neuroscience Society (ENCS) >Quantitative electroencephalographic abnormalities in fibromyalgia patients.
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Quantitative electroencephalographic abnormalities in fibromyalgia patients.

机译：纤维肌痛患者的定量脑电图异常。

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There is increasing acceptance that pain in fibromyalgia (FM) is a result of dysfunctional sensory processing in the spinal cord and brain, and a number of recent imaging studies have demonstrated abnormal central mechanisms. The objective of this report is to statistically compare quantitative electroencephalogram (qEEG) measures in 85 FM patients with age and gender matched controls in a normative database. A statistically significant sample (minimum 60 seconds from each subject) of artifact-free EEG data exhibiting a minimum split-half reliability ratio of 0.95 and test-retest reliability ratio of 0.90 was used as the threshold for acceptable data inclusion. FM subject EEG data was compared to EEGs of age and gender matched healthy subjects in the Lifespan Normative Database and analyzed using NeuroGuide 2.0 software. Analyses were based on spectral absolute power, relative power and coherence. Clinical evaluations included the Fibromyalgia Impact Questionnaire (FIQ), Beck Depression Inventory and Fischer dolorimetry for pain pressure thresholds. Based on Z-statistic findings, the EEGs from FM subjects differed from matched controls in the normative database in three features: (1) reduced EEG spectral absolute power in the frontal International 10-20 EEG measurement sites, particularly in the low- to mid-frequency EEG spectral segments; (2) elevated spectral relative power of high frequency components in frontal/central EEG measurement sites; and (3) widespread hypocoherence, particularly in low- to mid-frequency EEG spectral segments, in the frontal EEG measurement sites. A consistent and significant negative correlation was found between pain severity and the magnitude of the EEG abnormalities. No relationship between EEG findings and medicine use was found. It is concluded that qEEG analysis reveals significant differences between FM patients compared to age and gender matched healthy controls in a normative database, and has the potential to be a clinically useful tool for assessing brain function in FM patients.
机译：越来越多的人认为，纤维肌痛（FM）的疼痛是脊髓和大脑功能障碍的结果，最近的影像学研究已经证明了异常的中枢机制。本报告的目的是在规范数据库中统计比较85例年龄和性别相匹配的FM病人的定量脑电图（qEEG）量度。具有统计学意义的无伪造EEG数据样本（距每个受试者至少60秒），其最小半开可靠度比为0.95，重测信度比为0.90，被用作可接受数据的阈值。在Lifespan规范数据库中将FM受试者的EEG数据与年龄和性别匹配的健康受试者的EEG进行比较，并使用NeuroGuide 2.0软件进行分析。分析基于光谱绝对功率，相对功率和相干性。临床评估包括纤维肌痛影响问卷（FIQ），贝克抑郁量表和费歇尔（Fischer）量容法的疼痛压力阈值。基于Z统计量的结果，FM受试者的脑电图与规范数据库中的对照相比在以下三个方面有所不同：（1）在国际10-20个脑电图的正面测量站点中，尤其是在中低端，降低了脑电图谱的绝对功率频率脑电频谱段; （2）额叶/中央脑电测量部位高频成分的频谱相对功率升高; （3）在额叶脑电图测量部位普遍存在低相干性，特别是在中低频脑电波频谱段。疼痛严重程度与脑电图异常程度之间存在一致且显着的负相关。没有发现脑电图结果与药物使用之间的关系。结论是，qEEG分析显示在规范数据库中与年龄和性别匹配的健康对照相比，FM患者之间存在显着差异，并且有可能成为评估FM患者脑功能的临床有用工具。

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