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首页> 外文期刊>Journal of stroke and cerebrovascular diseases: The official journal of National Stroke Association >Silent cerebral infarcts and cerebral white matter lesions in patients with nonvalvular atrial fibrillation
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Silent cerebral infarcts and cerebral white matter lesions in patients with nonvalvular atrial fibrillation

机译：非瓣膜性房颤患者无症状的脑梗死和脑白质病变

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Background: Nonvalvular atrial fibrillation (NVAF) is a well-known strong risk factor for stroke, although few studies have examined silent cerebral ischemic lesions in patients with NVAF. We investigated silent cerebral infarcts (SCIs) and cerebral white matter lesions and risk factors for stroke in NVAF patients. Methods: Subjects included 71 consecutive patients with NVAF and 71 sex-and age-matched controls with sinus rhythm who had undergone MRI. Number, size, and localization of SCIs and severity of periventricular hyperintensity (PVH) and deep and subcortical white matter hyperintensity (DSWMH) on magnetic resonance imaging were analyzed. The risk factors and CHADS2 score for stroke were also investigated. Results: The number of SCIs was significantly larger and the rates of SCIs in the cortex/subcortex and deep white matter were higher in the NVAF group than in the control group. The DSWMH grade was also significantly higher in the NVAF group. NVAF was an independent risk factor for SCIs and DSWMH. The number of cortical and subcortical SCIs was significantly correlated with CHADS2 score. Conclusions: Cortical/subcortical and deep white matter SCIs were more frequent and DSWMH grades were higher in NVAF patients compared with control subjects. CHADS2 score was an effective scheme not only in stroke risk but also in risk of SCI.
机译：背景：非瓣膜性房颤（NVAF）是众所周知的中风的重要危险因素，尽管很少有研究检查了NVAF患者的沉默性脑缺血性病变。我们调查了NVAF患者的沉默性脑梗塞（SCI）和脑白质损害以及中风的危险因素。方法：受试者包括71名连续的NVAF患者和71名性别和年龄相匹配的窦性心律对照者，他们接受了MRI检查。分析了SCI的数量，大小和位置，以及磁共振成像中脑室周围高强度（PVH）和皮质深层和皮质下白质高强度（DSWMH）的严重程度。还调查了中风的危险因素和CHADS2评分。结果：NVAF组的SCI数量显着增加，并且皮层/皮层和深部白质中SCI的发生率高于对照组。 NVAF组的DSWMH评分也明显更高。 NVAF是SCI和DSWMH的独立危险因素。皮质和皮质下SCI的数量与CHADS2评分显着相关。结论：与对照组相比，NVAF患者的皮质/皮质下和深部白质SCI更为频繁，DSWMH评分更高。 CHADS2评分不仅是中风风险，而且是SCI风险的有效方案。

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