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首页> 外文期刊>Journal of stroke and cerebrovascular diseases: The official journal of National Stroke Association >Sequence Variants on Chromosome 9p21 Are Associated with Ischemic Stroke and the Lipids Level in Chinese Han Population
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Sequence Variants on Chromosome 9p21 Are Associated with Ischemic Stroke and the Lipids Level in Chinese Han Population

机译：中国汉族人群染色体9p21的序列变异与缺血性中风和血脂水平相关。

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Background: Several studies have demonstrated that variants on chromosome 9p21 confer susceptibility to ischemic stroke (IS) disease. But, the results of variants' roles in Chinese IS population are blank or inconsistent. Methods: We performed a case-control analysis in 116 patients with IS and 118 non-IS controls of Han background to determine whether 4 single nucleotide polymorphisms were associated with IS. DNA was extracted from saliva using a magnetic nanoparticles-based method. Results: After we adjusted for clinical parameters, we found that the rs10757278-GG genotype conveyed 1.88-fold (95% confidence interval [CI], 1.1-3.1; P = .015), the rs1537378-C allele conveyed 2.0-fold (95% CI, 1.2-3.5; P = .008), and the rs1333047-TT genotype conveyed 1.64-fold (95% CI, 1.02-2.6; P = .041) increased risk of IS, respectively. In addition, there is a significant difference of the lipids level between GG genotype compared with that of AA genotype in rs10757278 (P < .05). Conclusions: This study is the first one to demonstrate that the rs10757278-GG genotype, the rs1537378-C allele, and rs1333047-TT genotype are associated with IS in Chinese Han populations. More importantly, the variant of rs10757278 may have different degrees of influence on lipids level. (C) 2015 by National Stroke Association
机译：背景：多项研究表明，9p21染色体上的变异对缺血性中风（IS）疾病具有敏感性。但是，变体在中国IS人口中的作用结果是空白或不一致的。方法：我们对116例IS患者和118例汉族非IS患者进行了病例对照分析，以确定是否有4个单核苷酸多态性与IS相关。使用基于磁性纳米粒子的方法从唾液中提取DNA。结果：调整临床参数后，我们发现rs10757278-GG基因型可表达1.88倍（95％置信区间[CI]，1.1-3.1; P = .015），rs1537378-C等位基因可表达2.0倍（ 95％CI，1.2-3.5; P = .008），而rs1333047-TT基因型分别带来1.64倍（95％CI，1.02-2.6; P = .041）的IS风险增加。此外，在rs10757278中，GG基因型与AA基因型之间的脂质水平存在显着差异（P <.05）。结论：该研究是第一个证明rs10757278-GG基因型，rs1537378-C等位基因和rs1333047-TT基因型与中国汉族人群IS相关的研究。更重要的是，rs10757278的变体可能对脂质水平具有不同程度的影响。 （C）国家卒中协会2015年

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