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首页> 外文期刊>Journal of stroke and cerebrovascular diseases: The official journal of National Stroke Association >Seizures Following Ischemic Stroke: Frequency of Occurrence and Impact on Outcome in a Long-Term Population-Based Study
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Seizures Following Ischemic Stroke: Frequency of Occurrence and Impact on Outcome in a Long-Term Population-Based Study

机译：缺血性中风后的癫痫发作：一项长期的基于人群的研究的发生频率及其对结果的影响

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Background and Purpose: Seizures are a known complication of ischemic stroke (IS). This study assesses the long-term incidence and characteristics of poststroke seizures in a well-defined population. Methods: Using the Rochester Epidemiology Project medical records-linkage system, we identified all incident cases of IS among Rochester, Minnesota, residents from 1990 to 1994 and followed the patients in the comprehensive medical record through March 2014. All patients with poststroke seizures were identified, and data regarding incident IS, seizures, and status at last follow-up were analyzed. Results: We identified 489 patients with first IS. Mean follow-up was 6.5 (standard deviation 6.3) years. New onset seizures occurred in 35 patients (7.2%). Patients with poststroke seizure did not differ from those without in terms of IS etiologic subtype (P = .44) or IS risk factors (P > .05). Early seizures (within 14 days of index stroke) developed in 14 patients (40%), the majority within the first 24 hours (n = 9, 64.3%). The median time of seizure onset for the remaining 21 patients was 13.8 months. Functional outcome, as measured by modified Rankin Scale (mRS), was worse following development of poststroke seizures (mean mRS score 2.9 after IS, 3.3 following index seizure; P = .005), and mortality was higher as well, even after adjusting for IS etiologic subtype (HR 1.52, 95% confidence interval 1.07-2.16, P = .02). Conclusion: Development of poststroke seizures is an infrequent but significant complication of IS, portending a worse short-term functional outcome and a higher long-term mortality rate. Seizure occurrence did not differ based on IS etiologic subtype or stroke risk factors.
机译：背景和目的：癫痫发作是缺血性中风（IS）的已知并发症。这项研究评估了明确人群中脑卒中后癫痫的长期发病率和特征。方法：使用罗彻斯特流行病学项目医疗记录链接系统，我们确定了1990年至1994年间在明尼苏达州罗彻斯特，居民中发生的所有IS病例，并跟踪了患者的综合病历，直至2014年3月。确定了所有中风后发作的患者，并分析了有关事件IS，癫痫发作和上次随访状态的数据。结果：我们确定了489例首次IS患者。平均随访时间为6.5年（标准差6.3）。 35例患者（7.2％）发生新的发作。脑卒中后发作的患者与没有IS病因亚型（P = .44）或IS危险因素（P> .05）的患者没有区别。 14例患者（40％）发生了早期癫痫发作（索引性卒中的14天之内），大多数在头24小时内发作（n = 9，64.3％）。其余21例患者发作的中位时间为13.8个月。用改良的Rankin量表（mRS）衡量的功能结局在卒中后发作后变得更糟（IS后平均mRS评分为2.9，发作后平均癫痫发作为3.3; P = .005），即使进行校正后，死亡率也更高。 IS病因亚型（HR 1.52，95％置信区间1.07-2.16，P = .02）。结论：卒中后发作的发生是IS的罕见但重要并发症，预示着短期的功能预后较差，长期死亡率较高。根据IS病因亚型或中风危险因素，癫痫发作没有差异。

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