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首页> 外文期刊>Journal of stroke and cerebrovascular diseases: The official journal of National Stroke Association >White matter hyperintensity volume correlates with matrix metalloproteinase-2 in acute ischemic stroke
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White matter hyperintensity volume correlates with matrix metalloproteinase-2 in acute ischemic stroke

机译：急性缺血性脑卒中白质过高与基质金属蛋白酶2相关

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Background White matter hyperintensity (WMH), a common radiographic finding associated with stroke risk and outcome, has been linked to matrix metalloproteinase (MMP) activity and increased levels of oxidative stress in nonstroke populations. We sought to determine whether WMH severity is associated with plasma levels of MMPs and oxidative stress (F2-isoprostane) in subjects with acute ischemic stroke (AIS). Methods We measured plasma biomarker levels at baseline and 48 hours in consecutive AIS subjects. White matter hyperintensity volume (WMHv) was quantified on admission magnetic resonance imaging using a validated semiautomated protocol, and Spearman correlation coefficients were derived for all measured biomarkers. Results We enrolled 405 AIS subjects (mean age 70 ± 15 years; 58% male; median WMHv 3.4 cm3, interquartile range 1.4-9.5). WMHv and age were strongly correlated (ρ =.57, P .0001). WMHv and MMP-2 levels were correlated at baseline (ρ =.23, P .0001) and at 48 hours poststroke (ρ =.19, P =.002). In multivariate analysis, 48-hour MMP-2 levels were independently associated with WMHv (β =.12, P =.04). MMP-9 and F2-isioprostane levels did not correlate with WMHv. Conclusions In AIS patients, MMP-2 levels are associated with the pre-existing burden of WMH. If validated, these findings may further elucidate the role of MMP-2 in pathophysiology of chronic cerebrovascular injury, such as WMH, and in brain susceptibility to acute ischemia.
机译：背景白质高信号（WMH）是与中风风险和结果相关的常见影像学发现，与基质金属蛋白酶（MMP）活性和非中风人群氧化应激水平升高有关。我们试图确定WMH严重程度是否与患有急性缺血性卒中（AIS）的受试者的血浆MMPs水平和氧化应激（F2-异前列腺素）有关。方法我们测量了连续AIS受试者在基线和48小时的血浆生物标志物水平。使用经过验证的半自动化方案，在入院磁共振成像中对白质高血容量（WMHv）进行定量，并为所有测得的生物标志物得出Spearman相关系数。结果我们招募了405名AIS受试者（平均年龄70±15岁;男性58％;中位数WMHv 3.4 cm3，四分位间距1.4-9.5）。 WMHv与年龄密切相关（ρ= .57，P <.0001）。 WMHv和MMP-2水平在基线（ρ= .23，P <.0001）和中风后48小时（ρ= .19，P = .002）相关。在多变量分析中，48小时MMP-2水平与WMHv独立相关（β= .12，P = .04）。 MMP-9和F2-异前列腺素水平与WMHv不相关。结论在AIS患者中，MMP-2水平与WMH先前的负担有关。如果得到证实，这些发现可能会进一步阐明MMP-2在慢性脑血管损伤（例如WMH）的病理生理中以及在脑对急性缺血的敏感性中的作用。

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