...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of stroke and cerebrovascular diseases: The official journal of National Stroke Association >Modest Association between the Discharge Modified Rankin Scale Score and Symptomatic Intracerebral Hemorrhage after Intravenous Thrombolysis
【24h】

Modest Association between the Discharge Modified Rankin Scale Score and Symptomatic Intracerebral Hemorrhage after Intravenous Thrombolysis

机译：出院后改良Rankin量表评分与静脉溶栓后症状性脑出血之间的适度关联

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Background: Thirty- and 90-day modified Rankin Scale (mRS) scores are used to monitor adverse outcome or symptomatic intracerebral hemorrhage (sICH) in ischemic stroke patients after intravenous (IV) thrombolytic therapy. Discharge mRS scores are more readily available and could serve as a proxy for 30- or 90-day mRS data. Our goal was to evaluate agreement between the discharge mRS score and sICH. Additionally, we tested for correlations between the discharge mRS score and 8 clinical scores developed to predict sICH or adverse outcomes based on 90-day mRS data. Methods: Clinical data were analyzed from 210 patients receiving IV thrombolysis from January 2009 till December 2013 at the Yale New Haven Hospital. Agreement between sICH and the discharge mRS score was assessed using linear kappa. Eight clinical scores were calculated for each patient and compared with the discharge mRS score by univariate logistic regression. Goodness of fit was tested by receiver operating characteristic (ROC) analysis and by Hosmer-Lemeshow statistics. Results: We found only modest agreement between sICH and unfavorable discharge mRS scores (mRS >= 5), with kappa .22, P = .0001. All 8 clinical scores tested showed good agreement with discharge mRS score of 5 or more (ROC area.. 7). Conclusions: The discharge mRS score shows only modest agreement with sICH and therefore cannot be recommended as a proxy for 30- or 90-day mRS data. However, the discharge mRS score correlates strongly with clinical scores predicting long-term adverse outcome; therefore, assessment of discharge mRS scores may be of some clinical benefit.
机译：背景：30天和90天改良的Rankin量表（mRS）评分用于监测静脉内（IV）溶栓治疗后缺血性卒中患者的不良结局或症状性脑出血（sICH）。出院mRS得分更容易获得，可以代替30天或90天mRS数据。我们的目标是评估放电mRS评分与sICH之间的一致性。此外，我们测试了出院mRS评分与根据90天mRS数据预测sICH或不良结局而开发的8个临床评分之间的相关性。方法：分析2009年1月至2013年12月在耶鲁纽黑文医院接受静脉溶栓治疗的210例患者的临床资料。 sICH和放电mRS评分之间的一致性使用线性κ评估。为每位患者计算了8个临床评分，并通过单因素logistic回归将其与出院mRS评分进行了比较。拟合优度通过接收器工作特性（ROC）分析和Hosmer-Lemeshow统计数据进行了测试。结果：我们发现sICH与不良放电mRS评分（mRS> = 5）之间只有适度的一致性，kappa为.22，P = .0001。测试的所有8个临床评分均显示出院mRS评分为5或更高（ROC面积7）。结论：出院mRS评分与sICH仅显示适度的一致性，因此不建议将其作为30天或90天mRS数据的替代指标。然而，出院mRS评分与预测长期不良结局的临床评分高度相关。因此，评估出院mRS评分可能具有一定的临床意义。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号