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首页> 外文期刊>Journal of stroke and cerebrovascular diseases: The official journal of National Stroke Association >Height and risk of incident intraparenchymal hemorrhage: Atherosclerosis risk in communities and cardiovascular health study cohorts
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Height and risk of incident intraparenchymal hemorrhage: Atherosclerosis risk in communities and cardiovascular health study cohorts

机译：实质内出血的高度和风险：社区和心血管健康研究人群的动脉粥样硬化风险

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Background: Height is inversely associated with incident coronary disease and total stroke, but few studies have examined the association between height and intraparenchymal hemorrhage (IPH). We hypothesized that height would be inversely associated with incident IPH in the combined cohorts of the Atherosclerosis Risk in Communities Study and the Cardiovascular Health Study. Methods: Data on Caucasian and African American participants were used to estimate the association of height at baseline with incident IPH verified by clinician review of medical records and imaging reports. Sex-specific Cox proportional hazards regression models were used to calculate hazard ratios. Results: A total of 20,983 participants initially free of stroke (11,788 women and 9195 men) were followed for an average of 15.9 years (standard deviation [SD] 5.1 years). Incident IPH occurred in 115 women and 73 men. Sex, but not age, race, study, or blood pressure, modified the association (P =.03). After adjustment for risk factors (age, systolic blood pressure, triglycerides, low-density lipoprotein cholesterol, fibrinogen, and race), among women, height was significantly inversely associated with incident IPH (hazard ratio [HR] per SD [6.3 cm] was 0.81; 95% confidence interval [CI] 0.66-0.99; P =.04). The HR for tertile 3 vs 1 in women was 0.63 (95% CI 0.37-1.08). Among men, height was not linearly associated with incident IPH (HR per SD [6.7 cm] was 1.09; 95% CI 0.84-1.40; P = .52). Conclusions: This large prospective study provides evidence that shorter height may be a risk factor for incident IPH in women.
机译：背景：身高与突发性冠心病和中风成反比，但是很少有研究检查身高与实质内出血（IPH）之间的关系。在社区研究和心血管健康研究中，我们假设在动脉粥样硬化风险的组合队列中，身高与IPH的发生呈负相关。方法：使用有关白种人和非裔美国人参与者的数据，通过临床医生对病历和影像报告的审查来估计基线身高与IPH事件的关联。使用特定性别的Cox比例风险回归模型来计算风险比。结果：总共有20,983名最初无卒中的参与者（11,788名女性和9195名男性）被随访平均15.9年（标准差[SD] 5.1年）。 115名妇女和73名男子发生了IPH事件。性别，而不是年龄，种族，学习或血压，改变了这种关联（P = .03）。在调整了危险因素（年龄，收缩压，甘油三酯，低密度脂蛋白胆固醇，纤维蛋白原和种族）后，女性的身高与IPH的发生呈显着负相关（危险比[HR] / SD [6.3 cm]为0.81; 95％置信区间[CI] 0.66-0.99; P = .04）。女性三分位数3比1的HR为0.63（95％CI 0.37-1.08）。在男性中，身高与IPH的发病率不是线性相关的（每SD [6.7 cm]的HR为1.09; 95％CI 0.84-1.40; P = 0.52）。结论：这项大型的前瞻性研究提供了证据，证明身高矮可能是女性发生IPH的危险因素。

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