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首页> 外文期刊>Journal of stroke and cerebrovascular diseases: The official journal of National Stroke Association >Cortical Atrophy and White Matter Hyperintensities in HIV: The Hawaii Aging with HIV Cohort Study
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Cortical Atrophy and White Matter Hyperintensities in HIV: The Hawaii Aging with HIV Cohort Study

机译：HIV中的皮质萎缩和白色物质高信号：HIV队列研究的夏威夷衰老

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Background: As many human immunodeficiency virus (HlV)-seropositive individuals are now living longer after infection because of highly active antiretroviral therapy aging-related manifestations of cerebral small-vessel ischemic vascular disease, such as brain white matter hyperintensities (WMHs), are becoming increasingly important in this population. Goals: This study was designed to determine the relationship between WMHs and cortical volumes in HIV-seropositive individuals. Materials and Methods: Voxel-based morphometry was used to compare cortical volumes among 62 HIV-seropositive individuals participating in the Hawaii Aging with HIV Cohort Study 30 with moderate WMHs and 32 with minimal or no WMHs. Results: Presence of moderate WMHs was associated with decreased cortical volumes in the frontal lobes bilaterally. Conclusion: These findings suggest that age-related WMHs are associated with reduced frontal gray matter volumes in HIV-seropositive individuals, supporting the hypothesis that the frontal lobes may have greater susceptibility to the effects of small-vessel ischemic vascular disease.
机译：背景：由于高效的抗逆转录病毒疗法，与脑衰老相关的脑小血管缺血性血管病（例如脑白质高信号（WMHs））的表现，许多人类免疫缺陷病毒（HIV）血清阳性的人现在感染后的寿命更长。在这一人群中越来越重要。目标：本研究旨在确定HIV血清阳性个体中WMH与皮层体积之间的关系。材料和方法：基于体素的形态计量学用于比较参加夏威夷老龄化与HIV队列研究的62名HIV血清阳性个体中的皮质体积，其中30名中等WMH，32名最小WMH或无WMH。结果：中度WMHs的存在与双侧额叶皮质体积的减少有关。结论：这些发现表明，与年龄相关的WMH与HIV血清阳性患者的额叶灰质减少有关，支持以下假设：额叶对小血管缺血性血管疾病的敏感性更高。

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