• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of stroke and cerebrovascular diseases: The official journal of National Stroke Association >Protective Effect of Minocycline Treatment on Striatal Ischemia
【24h】

Protective Effect of Minocycline Treatment on Striatal Ischemia

机译：米诺环素治疗对纹状体缺血的保护作用

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Minocycline reduces infarct volume measured up to 1 week after focal cerebral ischemia, but it has not been shown that this results in lasting improvement in functional outcome. This study examined behavioral outcome in rats out to 3 weeks after focal ischemia induced by injection of the vasoconstrictor endothelin (ET)-1 (400 pmol in 1 μL of saline) into the striatum. Magnetic resonance imaging confirmed reduced blood flow after administration of ET-1, and was used to determine lesion volumes at 1 and 21 days postischemia. In control rats, intraperitoneal injection of minocycline resulted in plasma levels of 6.6 ± 2.7 μg mL-1 between 1 and 8 hours after administration. Based on these results, intraperitoneal minocycline treatment was started either 1 hour before or 3 hours after ET-1 administration, and was repeated daily for 5 days. Outcome, assessed using a composite behavioral deficit score (days 2, 4, 7, 14, and 21) and a test of asymmetric forelimb use (days 7 and 21), was significantly better in both groups of rats treated with minocycline, and the improvement was maintained for the 3-week study period. No differences were found in infarct volumes between groups. 2006 National Stroke Association.
机译：米诺环素可减少局灶性脑缺血后长达1周的梗塞面积，但尚未显示这会导致功能预后的持久改善。这项研究检查了大鼠局部缺血后3周内通过将血管收缩素（ET）-1（400 pmol在1μL盐水中）注入纹状体引起的行为行为。磁共振成像证实给予ET-1后血流量减少，并用于确定缺血后1天和21天的病变体积。在对照大鼠中，腹膜内注射米诺环素在给药后1至8小时内的血浆水平为6.6±2.7μgmL-1。基于这些结果，在给予ET-1之前1小时或之后3小时开始腹膜内美满霉素治疗，每天重复5天。使用综合行为缺陷评分（第2、4、7、14和21天）和不对称前肢使用测试（第7和21天）进行评估的结果，在接受米诺环素治疗的两组大鼠中均明显好于对照组，在为期3周的研究期内保持了改善。各组之间的梗死体积无差异。 2006年全国中风协会。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号