...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of stroke and cerebrovascular diseases: The official journal of National Stroke Association >Predictors of Clinical Outcome and Mortality in Vertebrobasilar Dolichoectasia Diagnosed by Magnetic Resonance Angiography
【24h】

Predictors of Clinical Outcome and Mortality in Vertebrobasilar Dolichoectasia Diagnosed by Magnetic Resonance Angiography

机译：核磁共振血管造影诊断脊椎椎管扩张症的临床结果和死亡率的预测因素

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Objective: Vertebrobasilar dolichoectasia (VBD) is a poorly understood vasculop-athy. VBD may be associated with an increased likelihood of stroke and all-cause mortality. The purpose of this study was to establish predictors for clinical outcome in VBD, and better guide therapeutic medical and surgical interventions. Methods: In all, 64 adult VBD cases diagnosed by magnetic resonance angiography were retrospectively identified and prospectively followed up (4-7 years). Inclusion criteria were age 18 years or older, VBD on magnetic resonance angiography, and consent to participate. Patients with inadequate follow-up data or hemodynamically significant stenosis or occlusion of the posterior circulation were excluded. Univariate and multivariate analyses were performed with predictor modeling in 45 VBD cases. Results: Basilar artery (BA) involvement was independently associated with the transient/fixed posterior circulation dysfunction (P = .03) with an adjusted odds ratio of 4.4 (95% confidence interval= 1.2-16.1). A combination of African American ethnicity, diabetes mellitus, peripheral vascular disease, smoking, and BA involvement predicted 31% of posterior circulation dysfunction, resulting in an annual predicted likelihood of stroke of 4.4% to 7.8% in this group. Hypertension, previous anterior and posterior circulation strokes, BA involvement, and lack of previous warfarin use predicted mortality in 23% of cases, resulting in an annual likelihood of death of 3.3% to 5.8% in patients with this combination of clinical and radiologic factors. Conclusions: In patients with VBD, BA involvement increases the risk of neurologic morbidity, whereas mortality seems more predicted by classic vascular risk factors than VBD features. This study may aid in predicting annual risk of stroke recurrence or death in VBD.
机译：目的：脊椎椎管疏松症（VBD）是一种鲜为人知的血管象。 VBD可能与中风和全因死亡率增加有关。这项研究的目的是建立VBD临床结果的预测指标，并更好地指导治疗性医学和外科手术干预。方法：回顾性分析并回顾性分析64例经磁共振血管造影确诊的成人VBD患者，并对其进行前瞻性随访（4-7年）。入选标准为18岁或18岁以上，磁共振血管造影上的VBD并同意参加。随访数据不足或血液动力学显着狭窄或后循环闭塞的患者被排除在外。使用预测变量模型对45例VBD病例进行单因素和多因素分析。结果：基底动脉受累与短暂性/固定性后循环功能障碍（P = .03）独立相关，校正比值比为4.4（95％置信区间= 1.2-16.1）。非裔美国人种族，糖尿病，周围血管疾病，吸烟和BA累及因素的组合预测了31％的后循环功能障碍，导致该组中风的年预测可能性为4.4％至7.8％。高血压，先前的前后循环卒中，BA累及以及先前使用华法林的缺乏可预测23％的病例死亡，因此，将这种临床和放射学因素相结合的患者每年的死亡可能性为3.3％至5.8％。结论：在VBD患者中，BA参与会增加神经系统疾病的风险，而经典血管危险因素似乎比VBD功能更能预测死亡率。这项研究可能有助于预测VBD中风复发或死亡的年度风险。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号