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首页> 外文期刊>Journal of stroke and cerebrovascular diseases: The official journal of National Stroke Association >Insulin Resistance in Patients with Stroke is Related to Visceral Fat Obesity and Adipocytokines
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Insulin Resistance in Patients with Stroke is Related to Visceral Fat Obesity and Adipocytokines

机译：中风患者的胰岛素抵抗与内脏脂肪肥胖和脂肪细胞因子有关

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摘要

Insulin resistance is associated with hyperglycemia and dyslipidemia and promotes atherosclerosis. Although insulin resistance is associated with adipocytokines, little is known about the association in patients with stroke without diabetes mellitus. The aim of the current study was to examine the relationship among insulin resistance, visceral fat area, and adipocytokines in patients with stroke. This study design was cross-sectional in a university hospital. We studied 60 patients with stroke and no history of diabetes mellitus who had hyperglycemia or hypertriglyceridemia or reduced fasting plasma high-density lipoprotein cholesterol. We measured insulin resistance, the plasma level of tumor necrosis factor (TNF)-alpha, adiponectin, and the visceral fat area. Insulin resistance was defined by the homeostasis model assessment and the level of insulin at 120 minutes after consuming oral glucose. We classified two groups (insulin sensitive or insulin resistant). In all, 21 of 60 patients (35.0%) had insulin resistance and 35 (58.3%) had hyperinsulinemia. Compared with insulin-sensitive patients with stroke (n = 18), insulin-resistant patients with stroke (n = 21) had significantly wider visceral fat areas and a high level of plasma TNF-alpha. The plasma level of adiponectin in insulin-resistant patients with stroke was similar to that in insulin-sensitive patients. Insulin-resistant patients with stroke in this study had a large amount of visceral fat and increased levels of TNF-alpha. We recommend that obese patients with stroke should be examined for insulin resistance to reduce the risk of the development of atherosclerosis.
机译：胰岛素抵抗与高血糖和血脂异常有关，并促进动脉粥样硬化。尽管胰岛素抵抗与脂肪细胞因子有关，但对于没有糖尿病的中风患者的关联还知之甚少。本研究的目的是检查中风患者的胰岛素抵抗，内脏脂肪面积和脂肪细胞因子之间的关系。这项研究设计是在一家大学医院进行的。我们研究了60例中风，无糖尿病史，高血糖或高甘油三酯血症或空腹血浆高密度脂蛋白胆固醇降低的患者。我们测量了胰岛素抵抗，血浆肿瘤坏死因子（TNF）-α，脂联素和内脏脂肪区的血浆水平。通过稳态模型评估和口服葡萄糖后120分钟时的胰岛素水平来定义胰岛素抵抗。我们分为两组（胰岛素敏感性或胰岛素抵抗性）。总共60例患者中有21例（35.0％）有胰岛素抵抗，而35例（58.3％）有高胰岛素血症。与胰岛素敏感的中风患者（n = 18）相比，胰岛素抵抗的中风患者（n = 21）的内脏脂肪区域明显更宽，血浆TNF-α水平较高。胰岛素抵抗中风患者的血浆脂联素水平与胰岛素敏感性患者相似。在这项研究中，胰岛素抵抗性中风患者的内脏脂肪过多，TNF-α水平升高。我们建议肥胖的中风患者应检查其胰岛素抵抗，以减少发生动脉粥样硬化的风险。

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