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首页> 外文期刊>Journal of the American Pharmacists Association: JAPhA >Recreational use and misuse of phosphodiesterase 5 inhibitors.
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Recreational use and misuse of phosphodiesterase 5 inhibitors.

机译：娱乐性使用和滥用磷酸二酯酶5抑制剂。

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OBJECTIVE: To characterize the rationale for and extent of phosphodiesterase (PDE) 5 inhibitor use in recreational settings, describe risks from such misuse, and discuss postexposure clinical management strategies. DATA SOURCES: Published articles identified by searches through Medline, EMBASE, International Pharmaceutical Abstracts, and Toxline, from 1990 to March 2004, using the search terms sildenafil, tadalafil, vardenafil, phosphodiesterase inhibitor, abuse, overdose, adverse effects, recreational, and street drugs. Additional references identified within articles and information from the Internet were included. STUDY SELECTION: Clinical trials, epidemiologic reviews, case reports, and news releases concerning the misuse of sildenafil. DATA EXTRACTION: By the authors. DATA SYNTHESIS: PDE5 inhibitors, indicated for treatment of erectile dysfunction, can produce several adverse effects, including potentially fatal cardiovascular events. Reports of recreational use and misuse of sildenafil appear in the medical literature and the media. The potential for abuse also exists for the two more recently approved drugs in this class, vardenafil and tadalafil. Increasing access to these drugs via the Internet may facilitate such misuse. Use in social settings has gained popularity, both in young, healthy patients, as well as those with chronic medical conditions, including human immunodeficiency virus infections. In these settings, the PDE5 inhibitors are sometimes used concomitantly with "club drugs" such as ketamine and amyl nitrite, leading to potentially harmful or fatal drug interactions. CONCLUSION: Pharmacists should be cognizant of the potential for PDE5 inhibitors to be misused, particularly in patients who are at greater risk of cardiovascular complications, and should advise patients and other health care professionals accordingly.
机译：目的：鉴定娱乐场所使用磷酸二酯酶（PDE）5抑制剂的原理和程度，描述滥用的风险，并讨论暴露后的临床管理策略。数据来源：1990年至2004年3月，通过搜索Medline，EMBASE，International Pharmaceutical Abstracts和Toxline进行搜索的已发表文章，使用搜索词sildenafil，tadalafil，vardenafil，磷酸二酯酶抑制剂，滥用，过量，不良反应，娱乐性和休闲性毒品。还包括文章和Internet信息中标识的其他参考。研究选择：有关西地那非滥用的临床试验，流行病学评论，病例报告和新闻稿。数据提取：作者。数据合成：PDE5抑制剂可治疗勃起功能障碍，可产生多种不良反应，包括可能致命的心血管事件。关于西地那非的娱乐性使用和滥用的报道出现在医学文献和媒体中。伐地那非和他达拉非这两种新近批准的药物也存在滥用的可能性。通过互联网增加对这些药物的访问可能会促进这种滥用。无论是在年轻，健康的患者中，还是在患有慢性疾病，包括人类免疫缺陷病毒感染的患者中，在社会环境中的使用都已普及。在这些情况下，PDE5抑制剂有时会与“俱乐部药物”（如氯胺酮和亚硝酸戊酯）同时使用，从而导致潜在的有害或致命的药物相互作用。结论：药剂师应认识到PDE5抑制剂可能被滥用，尤其是在心血管并发症风险较高的患者中，并应相应建议患者和其他卫生保健专业人员。

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