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首页> 外文期刊>Clinical EEG and neuroscience: official journal of the EEG and Clinical Neuroscience Society (ENCS) >Differential neurophysiological effects of magnetic seizure therapy (MST) and electroconvulsive shock (ECS) in non-human primates.
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Differential neurophysiological effects of magnetic seizure therapy (MST) and electroconvulsive shock (ECS) in non-human primates.

机译：非人类灵长类动物的癫痫发作（MST）和惊厥性电击（ECS）的差异神经生理作用。

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Magnetic seizure therapy (MST) is under development as a means of reducing the side effects of electroconvulsive therapy (ECT) through enhanced control over patterns of seizure induction and spread. We previously reported that chronic treatment with MST resulted in less impairment in cognitive function than electroconvulsive shock (ECS) in a non-human primate model of convulsive therapy. Here we present quantitative analyses of ictal expression and post-ictal suppression following ECS, MST, and anesthesia-alone sham in the same model to test whether differential neurophysiological characteristics of the seizures could be identified. Rhesus monkeys received 4 weeks of daily treatment with ECS, MST, and anesthesia-alone sham in a counterbalanced order separated by a recovery period. Both ECS and MST were given bilaterally at 2.5 x seizure threshold. Neurophysiological characteristics were derived from two scalp EEG electrode recording sites during and immediately following the ictal period, and were compared to sham treatment. EEG power within four frequencies (delta, theta, alpha and beta) was calculated. Our results support earlier findings from intracerebral electrode recordings demonstrating that MST- and ECS- induced seizures elicit differential patterns of EEG activation. Specifically, we found that ECS shows significantly more marked ictal expression, and more intense post-ictal suppression than MST in the theta, alpha, and beta frequency bands (Ps < .05). However, the ECS and MST were indistinguishable in the delta frequency band during both ictal and post-ictal periods. These results demonstrate that magnetic seizure induction can result in seizures that differ in some neurophysiological respects compared with ECS, but that these modalities share some aspects of seizure expression. The clinical significance of these similarities and differences awaits clinical correlation.
机译：磁化癫痫治疗（MST）正在开发中，可通过增强对癫痫发作诱发和扩散模式的控制来减少电痉挛治疗（ECT）的副作用。我们先前曾报道，在非人类灵长类动物惊厥治疗模型中，MST的慢性治疗比电惊厥休克（ECS）引起的认知功能损害更少。在这里，我们介绍了在同一模型中对ECS，MST和仅麻醉的假手术后的发作表达和发作抑制进行定量分析，以测试是否可以识别出癫痫发作的不同神经生理特征。恒河猴每天以平衡的顺序接受ECS，MST和仅麻醉麻醉的假手术4周，并以恢复期分开。 ECS和MST均以2.5 x发作阈值双侧给予。在发作期和发作期之后，从两个头皮脑电图电极记录部位得出神经生理学特征，并将其与假手术进行比较。计算了四个频率（δ，θ，α和β）内的EEG功率。我们的研究结果支持了脑内电极记录的早期发现，表明MST和ECS诱发的癫痫发作诱发了脑电图激活的不同模式。具体而言，我们发现，在θ，α和β频段中，与MST相比，ECS显示出明显的更明显的ictal表达和更强烈的ictal表达抑制（Ps <.05）。但是，在离散期和离散期，ECS和MST在增量频带中是无法区分的。这些结果表明，与ECS相比，磁性癫痫发作可导致癫痫发作在某些神经生理学方面有所不同，但这些方式共享癫痫发作表达的某些方面。这些相似性和差异的临床意义正在等待临床相关性。

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