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首页> 外文期刊>Journal of the American Veterinary Medical Association >Glucocorticoid deficient hypoadrenocorticism in dogs: 18 cases (1986-1995)
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Glucocorticoid deficient hypoadrenocorticism in dogs: 18 cases (1986-1995)

机译：犬糖皮质激素缺乏症肾上腺皮质激素缺乏症：18例（1986-1995）

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摘要

Hypoadrenocorticism is a well-recognized syndrome that classically includes mineralocorticoid and glucocorticoid deficiency. Clinical signs typically include debility and weakness, lethargy and signs of depression, vomiting, diarrhea, weight loss, hypotension, polyuria and polydipsia, and decreased appetite Electrolyte imbalance (hyporiatremia and hyperkalemia) caused by mineralocorticoid deficiency is the hallmark of this disease. In previous reports of hypoadrenocorticism, 11 to 26% of affected dogs had serum concentrations of sodium, potassium, or both that were within reference ranges, but such reports provide little specific information about this subgroup. Although iatrogenic glucocorticoid deficiency is fairly common in association with o,p'DDD or corticosteroid treatment, few reports in the literature focused on naturally developing deficiency of glucocorticoids alone, without concurrent mineralocorticoid deficiency. Therefore, the objective of the study reported here was to further characterize naturally acquired glucocorticoid deficiency in dogs.
机译：肾上腺皮质功能减退症是一种公认​​的综合征，典型地包括盐皮质激素和糖皮质激素缺乏症。临床体征通常包括虚弱和虚弱，嗜睡和沮丧，呕吐，腹泻，体重减轻，低血压，多尿症和多尿症以及食欲下降（由盐皮质激素缺乏引起的电解质失衡）（低渗血症和高钾血症），是这种疾病的标志。在先前的肾上腺皮质功能减退症的报告中，有11％至26％的患病犬的钠，钾或两者的血清浓度均在参考范围内，但此类报告几乎没有提供有关该亚组的具体信息。尽管医源性糖皮质激素缺乏症与o，p'DDD或皮质类固醇激素治疗相当普遍，但文献中很少有报道侧重于仅自然发展的糖皮质激素缺乏症，而没有并发盐皮质激素缺乏症。因此，本文报道的研究目的是进一步鉴定狗的自然获得性糖皮质激素缺乏症。

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