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首页> 外文期刊>Clinical EEG and neuroscience: official journal of the EEG and Clinical Neuroscience Society (ENCS) >Quantitative EEG and Current Source Density Analysis of Combined Antiepileptic Drugs and Dopaminergic Agents in Genetic Epilepsy: Two Case Studies
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Quantitative EEG and Current Source Density Analysis of Combined Antiepileptic Drugs and Dopaminergic Agents in Genetic Epilepsy: Two Case Studies

机译：遗传性癫痫中抗癫痫药物和多巴胺能药物合用的定量脑电图和电流源密度分析：两个案例研究

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Two adolescent females with absence epilepsy were classified, one as attention deficit and the other as bipolar disorder. Physical and cognitive exams identified hypotension, bradycardia, and cognitive dysfunction. Their initial electroencephalograms (EEGs) were considered slightly slow, but within normal limits. Quantitative EEG (QEEG) data included relative theta excess and low alpha mean frequencies. A combined treatment of antiepileptic drugs with a catecholamine agonist/reuptake inhibitor was sequentially used. Both patients' physical and cognitive functions improved and they have remained seizure free. The clinical outcomes were correlated with statistically significant changes in QEEG measures toward normal Z-scores in both anterior and posterior regions. In addition, low resolution electromagnetic tomography (LORETA) Z-scored source correlation analyses of the initial and treated QEEG data showed normalized patterns, supporting a neuroanatomic resolution. This study presents preliminary evidence for a neurophysiologic approach to patients with absence epilepsy and comorbid disorders and may provide a method for further research.
机译：将两名患有癫痫病的青春期女性分类为注意力缺陷，另一名为躁郁症。身体和认知检查可确定低血压，心动过缓和认知功能障碍。他们的初始脑电图（EEG）被认为稍慢，但在正常范围内。脑电图（QEEG）的定量数据包括相对theta过剩和低α平均频率。依序使用儿茶酚胺激动剂/再摄取抑制剂联合治疗抗癫痫药物。病人的身体和认知功能均得到改善，并且没有癫痫发作。临床结果与前后区域QEEG指标朝着正常Z评分的统计学显着变化相关。此外，对初始QEEG数据和处理过的QEEG数据的低分辨率电磁层析成像（LORETA）Z评分源相关分析显示归一​​化模式，支持神经解剖学分辨率。这项研究为缺乏癫痫和合并症的患者提供了神经生理学方法的初步证据，并可能提供进一步研究的方法。

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