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首页> 外文期刊>Journal of the American Academy of Child and Adolescent Psychiatry >Normalization of cortical gray matter deficits in nonpsychotic siblings of patients with childhood-onset schizophrenia.
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Normalization of cortical gray matter deficits in nonpsychotic siblings of patients with childhood-onset schizophrenia.

机译：儿童期精神分裂症患者非精神病性兄弟姐妹皮层灰质缺陷的正常化。

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OBJECTIVE: Cortical gray matter (GM) abnormalities in patients with childhood-onset schizophrenia (COS) progress during adolescence ultimately localizing to prefrontal and temporal cortices by early adult age. A previous study of 52 nonpsychotic siblings of COS probands had significant prefrontal and temporal GM deficits that appeared to "normalize" by age 17 years. Here we present a replication with nonoverlapping groups of healthy full siblings and healthy controls. METHOD: Using an automated measure and prospectively acquired anatomical brain magnetic resonance images, we mapped cortical GM thickness in nonpsychotic full siblings (n = 43, 68 scans; ages 5 through 26 years) of patients with COS, contrasting them with age-, gender-, and scan interval-matched healthy controls (n = 86, 136 scans). The false-discovery rate procedure was used to control for type I errors due to multiple comparisons. RESULTS: As in our previous study, young nonpsychotic siblings (<17 years) showed significant GM deficits in bilateral prefrontal and left temporal cortices and, in addition, smaller deficits in the parietal and right inferior temporal cortices. These deficits in nonpsychotic siblings normalized with age with minimal abnormalities remaining by age 17. CONCLUSIONS: Our results support previous findings showing nonpsychotic siblings of COS probands to have early GM deficits that ameliorate with time. At early ages, prefrontal and/or temporal loss may serve as a familial/trait marker for COS. Late adolescence appears to be a critical period for greatest localization of deficits in probands or normalization in nonpsychotic siblings.
机译：目的：儿童期精神分裂症（COS）患者的皮质灰质（GM）异常在青春期进展，最终在成年早期定位于额叶皮层和颞叶皮层。先前对52位COS先证者的非精神病性兄弟姐妹进行的研究显示，前额和颞叶GM的明显缺陷似乎在17岁时“正常化”。在这里，我们提出了健康全兄弟姐妹和健康对照的非重叠组的复制。方法：使用自动测量和前瞻性采集的解剖脑磁共振图像，我们绘制了COS患者的非精神病性全兄弟姐妹（n = 43、68扫描; 5至26岁）的皮层GM厚度图，并将其与年龄，性别进行了对比-，并扫描间隔匹配的健康对照（n = 86，136次扫描）。错误发现率程序用于控制由于多次比较而导致的I型错误。结果：与我们以前的研究一样，年轻的非精神病兄弟姐妹（<17岁）在双侧前额叶和左侧颞皮质中表现出明显的GM缺陷，此外，顶叶和右侧下颞皮质中的GM缺陷较小。非精神病性兄弟姐妹的这些缺陷随年龄恢复正常，到17岁时剩余的异常现象最少。结论：我们的结果支持以前的发现，表明COS先证者的非精神病性兄弟姐妹的早期GM缺陷随着时间的推移而减轻。在早期，前额叶和/或颞叶缺失可能是COS的家族/特征标记，青春期后期是先证者缺陷最大定位或非精神病性兄弟姐妹正常化的关键时期。

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