• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of the American Academy of Child and Adolescent Psychiatry >Comparison of Increasingly Detailed Elicitation Methods for the Assessment of Adverse Events in Pediatric Psychopharmacology.
【24h】

Comparison of Increasingly Detailed Elicitation Methods for the Assessment of Adverse Events in Pediatric Psychopharmacology.

机译：儿科心理药理学不良反应评估中越来越详尽的启发方法的比较。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

OBJECTIVE:: To improve the gathering of adverse events (AEs) in pediatric psychopharmacology by examining the value and acceptability of increasingly detailed elicitation methods. METHOD:: Trained clinicians administered the Safety Monitoring Uniform Report Form (SMURF) to 59 parents and outpatients (mean age +/- SD = 11.9 +/- 3.2 years) in treatment, with 36% on stimulants, 29% on selective serotonin reuptake inhibitor drugs, 10% on both, and 25% on other drug combinations. The SMURF included a brief general inquiry, a drug-specific inquiry, and a comprehensive body system review (BSR). RESULTS:: SMURF administration took 24.6 +/- 13.9 minutes (median, 21). The BSR took 15.5 +/- 8.1 minutes (median, 14) longer (p < .0001) than the general inquiry (4.3 +/- 5.4 minutes) and the drug-specific inquiry (4.2 +/- 2.9 minutes). The general inquiry elicited 48 AEs, the drug-specific inquiry elicited 16 additional AEs, and the BSR 129 additional AEs. Of all the clinically relevant AEs elicited by the SMURF (n =36), 19 (53%) were elicited by the BSR. The BSR length and detail were acceptable to parents but not to clinicians. CONCLUSIONS:: The BSR elicited additional clinically significant AEs that had been missed with less detailed methods. Parents, but not clinicians, rated satisfaction and acceptability of the BSR as good.
机译：目的：通过检查日益详细的启发方法的价值和可接受性，以改善儿科心理药理学中不良事件（AE）的收集。方法：：受过训练的临床医生向59位父母和门诊患者（平均年龄+/- SD = 11.9 +/- 3.2岁）施行了安全监测统一报告表（SMURF），其中兴奋剂36％，选择性5-羟色胺再摄取29％抑制剂药物，两者均为10％，其他药物组合为25％。 SMURF包括简短的一般询问，针对特定药物的询问以及全面的身体系统评价（BSR）。结果：SMURF的给药时间为24.6 +/- 13.9分钟（中位数为21）。 BSR比一般询问（4.3 +/- 5.4分钟）和药物特异性询问（4.2 +/- 2.9分钟）长15.5 +/- 8.1分钟（中位数为14）（p <.0001）。一般询问引起48种AE，针对药物的询问引起16种另外的AE，而BSR 129种引起另外的AE。由SMURF引发的所有临床相关AE（n = 36）中，有19例（53％）是由BSR引起的。 BSR的长度和详细信息对父母而言是可接受的，但临床医生不可接受。结论：BSR引发了其他临床上有意义的不良事件，而这些不良事件由于较不详尽的方法而被遗漏了。父母（而不是临床医生）将BSR的满意度和可接受性评为良好。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号