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首页> 外文期刊>Journal of the European Academy of Dermatology and Venereology: JEADV >Clinical profile of generalized vitiligo patients with associated autoimmune/autoinflammatory diseases
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Clinical profile of generalized vitiligo patients with associated autoimmune/autoinflammatory diseases

机译：伴有自身免疫性/自身炎性疾病的广义白癜风患者的临床概况

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Background The significance of associated autoimmune/autoinflammatory diseases in generalized vitiligo patients with respect to their clinical profile has not yet been completely established. Objective The objective of this study was to evaluate the clinical significance of associated autoimmune/ autoinflammatory diseases in generalized vitiligo patients with respect to some general clinical variables, distribution pattern, disease activity and treatment response. Methods Seven hundred generalized vitiligo patients were included in this retrospective observational cohort study. Results Associated autoimmune/autoinflammatory diseases were present in 15.4% of the patient population and were more common in women compared with men, especially concerning thyroid disease. Only vitiligo patients with thyroid disease had clear different clinical characteristics. The percentage of total body surface area involvement was significantly (P = 0.005) higher in the presence of thyroid disease which was more pronounced in women compared with men. Patients with thyroid disease had a particular predisposition to acral and joint depigmentations. No clear differences in disease activity or response to therapy were observed in vitiligo patients with or without autoimmune/autoinflammatory disorders. Conclusion The presence of associated autoimmune/autoinflammatory diseases seems to influence the clinical profile of generalized vitiligo patients. Our results support the hypothesis that in the presence of a thyroid disorder, the disease activity of vitiligo is more extensive, in particular on areas prone to friction.
机译：背景技术关于全身性白癜风患者的相关自身免疫/自身炎性疾病在其临床特征方面的重要性尚未完全确定。目的本研究的目的是就一些一般的临床变量，分布模式，疾病活动和治疗反应，评估广义白癜风患者相关的自身免疫性/自身炎性疾病的临床意义。方法这项回顾性观察队列研究纳入了700例白癜风患者。结果相关的自身免疫性/自身发炎性疾病占患者总数的15.4％，女性比男性多见，尤其是在甲状腺疾病方面。只有患有甲状腺疾病的白癜风患者具有明显不同的临床特征。在甲状腺疾病的存在下，涉及总表面积的百分比显着较高（P = 0.005），与男性相比，女性更为明显。甲状腺疾病患者特别容易发生髋臼和关节色素沉着。在患有或不患有自身免疫性/自身炎性疾病的白癜风患者中，未观察到疾病活动或对治疗反应的明显差异。结论相关的自身免疫性/自身炎性疾病的存在似乎会影响广义白癜风患者的临床情况。我们的结果支持以下假设：在存在甲状腺疾病的情况下，白癜风的疾病活动性更加广泛，尤其是在容易产生摩擦的区域。

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