...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of the Chemical Society, Dalton Transactions. Inorganic Chemistry >Synthesis, structures and hypoxia-selective cytotoxicity of cobalt(III) complexes containing tridentate amine and nitrogen mustard ligands
【24h】

Synthesis, structures and hypoxia-selective cytotoxicity of cobalt(III) complexes containing tridentate amine and nitrogen mustard ligands

机译：含三齿胺和氮芥子配体的钴（III）配合物的合成，结构和低氧选择性细胞毒性

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Cobalt(III) complexes containing the tridentate nitrogen mustard ligand N,N-bis(2-chloroethyl)diethylenetriamine (DCD) and the non-alkylating analogs N,N-diethyldiethylenetriamine (DED) and diethylenetriamine (dien) have been synthesised and the mustard complexes evaluated as potential hypoxia-selective anticancer drugs. The complexes were prepared from the precursor trans-K-2[Co(acac)(CO3)(NO2)(2)]. H2O in a charcoal-catalyzed substitution reaction. Reaction of this precursor with dien . 3HCl in water resulted in the isolation of two isomeric products, mer- and s-fac- [Co(dien)(acac)(NO2)](+). Reaction in methanol with DED . 3HCl gave one product, mer-[Co(DED)(acac)(NO2)]ClO4, while from the reaction with DCD . 3HCl both the tridentate mustard complex mer-[Co(DCD)(acac)(NO2)]ClO4 and, in low yield, a complex containing DCD coordinated in a bidentate fashion, trans-Co(eta(2)-DCD)(acac)(NO2)(2), were isolated. The two DCD complexes were characterized by X-ray structure determinations, which con rm the tridentate coordination with a long cobalt-tertiary nitrogen bond distance in the former, and bidentate coordination with the mustard nitrogen as a pendant arm in the latter. The bidentate complex, which contains a free nitrogen mustard, had cytotoxicity similar to that of the free ligand, but cytotoxicity was successfully masked in the tridentate complex, which showed modest hypoxic selectivity (five-fold) in a clonogenic assay. [References: 23]
机译：含有三齿氮芥子配体N，N-双（2-氯乙基）二亚乙基三胺（DCD）和非烷基化类似物N，N-二乙基二亚乙基三胺（DED）和二亚乙基三胺（dien）的钴（III）配合物已经合成，并且芥末配合物被评估为潜在的缺氧选择性抗癌药物。从前体反式K-2 [Co（acac）（CO3）（NO2）（2）]制备配合物。木炭催化的取代反应中的H2O。该前体与二烯的反应。水中的3HCl分离出两种异构产物，mer-和s-fac- [Co（dien）（acac）（NO2）]（+）。在甲醇中与DED反应。 3HCl从与DCD的反应中得到一种产物mer- [Co（DED）（acac）（NO 2）] ClO 4。 3HCl既包括三齿芥末配合物mer- [Co（DCD）（acac）（NO2）] ClO4，也包括低收率的，含有以双齿形式配位的DCD的复合物，即反式Co（eta（2）-DCD）（acac ）（NO2）（2）被分离。两种DCD配合物的特征在于X射线结构测定，前者证实三齿配位与长的钴-叔氮键距离，后者则以芥菜氮作为侧链来配位。含有游离氮芥子的二齿复合物具有与游离配体相似的细胞毒性，但在三齿复合物中成功掩盖了细胞毒性，在克隆形成测定中显示适度的低氧选择性（5倍）。 [参考：23]

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号