...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of the International Neuropsychological Society: JINS >Can risk-taking be an endophenotype for bipolar disorder? A study on patients with bipolar disorder type I and their first-degree relatives
【24h】

Can risk-taking be an endophenotype for bipolar disorder? A study on patients with bipolar disorder type I and their first-degree relatives

机译：冒险可以成为双相情感障碍的内表型吗？ I型双相情感障碍患者及其一级亲属的研究

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Abstract Risk-taking behavior and impulsivity are core features of bipolar disorder. Whether they are part of the inherited aspect of the illness is not clear. We aimed to evaluate risk-taking behavior as a potential endophenotype for bipolar disorders, and its relationship with impulsivity and illness features. The Balloon Analogue Risk Task (BART) and Barratt Impulsiveness Scale-11 (BIS-11) were used to assess risk-taking behavior and impulsivity respectively in 30 euthymic bipolar I patients (BD), their 25 asymptomatic first-degree relatives (BD-R), and 30 healthy controls (HC). The primary BART outcome measure was the behavioral adjustment score (number of pumps after trials where the balloon did not pop minus the number of pumps after trials where the balloon popped). BD (p <.001) and BD-R (p =.001) had similar and significantly lower adjustment scores than HC. Only BD scored significantly higher on BIS-11 total (p =.01) and motor (p =.04) subscales than HC. Neither the BART, nor impulsivity scores associated with illness features. A limitation of this study is medicated patients and a heterogeneous BD-R were included. Riskiness may be a candidate endophenotype for bipolar disorder as it appears independently from illness features, presents similarly in BD and BD-R groups and differs from impulsivity. (JINS, 2013, 19, 1-9)
机译：摘要冒险行为和冲动性是躁郁症的核心特征。它们是否是疾病遗传的一部分尚不清楚。我们旨在评估冒险行为作为双相情感障碍的潜在内表型，及其与冲动和疾病特征的关系。使用气球模拟风险任务（BART）和Barratt冲动量表11（BIS-11）分别评估了30名正常人双相I型患者（BD）及其25名无症状一级亲属（BD-）的冒险行为和冲动。 R）和30个健康对照（HC）。 BART的主要结局指标是行为调整评分（试验后气球未弹出的泵数减去试验后气球弹出的泵数）。 BD（p <.001）和BD-R（p = .001）与HC相似，且调整分数明显低于HC。只有BD在BIS-11总分（p = .01）和运动（p = .04）子量表上的得分明显高于HC。 BART或冲动得分均与疾病特征无关。该研究的局限性是含药患者和异质性BD-R。风险可能是双相情感障碍的候选内表型，因为它独立于疾病特征而出现，在BD和BD-R组中相似，并且与冲动性不同。 （JINS，2013，19，1-9）

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号