Reaction of Pyrimidinonethione Derivatives:Synthesis of N-methyl-2-hydrizinopyrimidine-4-one,thiazolo[3,4-b] N-methylpyrimidinone;2-(1-pyrazolonyl) N-methylpyrimidine-4-one and 2-Hydrazino-N-methyl pyrimidine-4-one Derivatives

Abdullah A.Al-Karim Al-Sharaey

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Reaction of Pyrimidinonethione Derivatives:Synthesis of N-methyl-2-hydrizinopyrimidine-4-one,thiazolo[3,4-b] N-methylpyrimidinone;2-(1-pyrazolonyl) N-methylpyrimidine-4-one and 2-Hydrazino-N-methyl pyrimidine-4-one Derivatives

机译：嘧啶酮硫酮衍生物的反应：N-甲基-2-肼基嘧啶-4-酮，噻唑并[3,4-b] N-甲基嘧啶酮; 2-（1-吡唑啉基）N-甲基嘧啶-4-酮和2-肼基-嘧啶酮的合成N-甲基嘧啶-4-酮衍生物

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6-Aryl-5-cyano-4-pyrimidinone-2-thion derivatives la-c reacted with methyl iodide (1:2) to give the corresponding 2-S,N-dimethyl pyrimidine-4-one derivatives 2a-c.Compounds 2a-c were in turn,reacted with hydrazine hydrate to give the sulfur free reaction products 3a-c.These reaction products were taken as the starting materials for the synthesis of several new heterocyclic derivatives.Reaction of 3a-c with acetic anhydride and formic acid gave pyrimido triazines 4a-c and 7a-c,respectively.Their reactions with active methyl-ene containing reagents gave the corresponding 2-(l-pyrazonyl)-N-methyl pyrimidine derivatives 9a-c and 10a-c,respectively.Their reactions with aromatic aldehydes afforded the corresponding 2-hydrazono pyrimidine derivatives 11a-c.The structure of these reactions products were established based on both elemental analysis and spectral data studies.

机译：将6-芳基-5-氰基-4-嘧啶酮-2-硫酮衍生物1a-c与碘甲烷（1：2）反应，得到相应的2-S，N-二甲基嘧啶-4-酮衍生物2a-c。然后将2a-c与水合肼反应，得到无硫反应产物3a-c。这些反应产物被用作合成几种新的杂环衍生物的起始原料.3a-c与乙酸酐和甲酸的反应它们分别与嘧啶三嗪4a-c和7a-c发生反应。它们与含活性亚甲基的试剂反应分别得到相应的2-（1-吡唑基）-N-甲基嘧啶衍生物9a-c和10a-c。与芳族醛的反应得到相应的2-hydr嗪嘧啶衍生物11a-c。基于元素分析和光谱数据研究，确定了这些反应产物的结构。

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《Journal of the Chinese Chemical Society.》 |2004年第3期|共6页
作者
Abdullah A.Al-Karim Al-Sharaey;
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正文语种 eng
中图分类化学;
关键词
pyrimidinethione; pyrimidine; triazine; pyrazolopyrimidine and hydrazo pyrimidine;

机译：嘧啶硫酮;嘧啶;三嗪;吡唑并嘧啶和肼基嘧啶;

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1. Reaction of Pyrimidinonethione Derivatives:Synthesis of N-methyl-2-hydrizinopyrimidine-4-one,thiazolo[3,4-b] N-methylpyrimidinone;2-(1-pyrazolonyl) N-methylpyrimidine-4-one and 2-Hydrazino-N-methyl pyrimidine-4-one Derivatives [J] . Abdullah A.Al-Karim Al-Sharaey Journal of the Chinese Chemical Society. . 2004,第3期

机译：嘧啶酮硫酮衍生物的反应：N-甲基-2-肼基嘧啶-4-酮，噻唑并[3,4-b] N-甲基嘧啶酮; 2-（1-吡唑啉基）N-甲基嘧啶-4-酮和2-肼基-嘧啶酮的合成N-甲基嘧啶-4-酮衍生物
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Reaction of Pyrimidinonethione Derivatives:Synthesis of N-methyl-2-hydrizinopyrimidine-4-one,thiazolo[3,4-b] N-methylpyrimidinone;2-(1-pyrazolonyl) N-methylpyrimidine-4-one and 2-Hydrazino-N-methyl pyrimidine-4-one Derivatives

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