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首页> 外文期刊>Journal of the Korean Society for Applied Biological Chemistry >Effects of Ramie Leaf Extract on Blood Glucose and Lipid Metabolism in db/db Mice
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Effects of Ramie Leaf Extract on Blood Glucose and Lipid Metabolism in db/db Mice

机译：of麻叶提取物对db / db小鼠血糖和脂质代谢的影响

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Hypoglycemic and hypolipidemic effects of ramie leaf ethanol extract (RLE) on C75BL/KsJ-db/db mice were determined. The db/db mice were divided into diabetic control group (C), two experimental groups orally treated with low dose (200 mg/k, RLEL) and high dose (400 mg/kg, RLEH) of RLE. After 6 weeks, fasting blood glucose, serum insulin, and glycosylated hemoglobin levels decreased in RLE groups compared to those in the control group. The glucose levels in the oral glucose tolerance test and area under the curve for glucose in the RLE groups were also significantly lower than those in the control group (p < 0.05). The serum total cholesterol and low-density lipoprotein cholesterol levels were significantly decreased in the RLEH group, whereas the serum HDL-cholesterol level was significantly increased in the RLEH group (p < 0.05). These data suggest that RLE may improve blood glucose and lipid metabolism in mice with type 2 diabetes
机译：确定了of麻叶乙醇提取物（RLE）对C75BL / KsJ-db / db小鼠的降血糖和降血脂作用。将db / db小鼠分为糖尿病对照组（C），口服低剂量（200 mg / k，RLEL）和高剂量（400 mg / kg，RLEH）的两个实验组。 6周后，与对照组相比，RLE组的空腹血糖，血清胰岛素和糖基化血红蛋白水平下降。 RLE组的口服葡萄糖耐量试验中的葡萄糖水平和葡萄糖曲线下面积也显着低于对照组（p <0.05）。 RLEH组的血清总胆固醇和低密度脂蛋白胆固醇水平显着降低，而RLEH组的血清HDL-胆固醇水平显着升高（p <0.05）。这些数据表明RLE可能改善2型糖尿病小鼠的血糖和脂质代谢

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