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首页> 外文期刊>Journal of the Society for Gynecologic Investigation >Clinical response, vascular change, and angiogenesis in gonadotropin-releasing hormone analogue-treated women with uterine myomas.
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Clinical response, vascular change, and angiogenesis in gonadotropin-releasing hormone analogue-treated women with uterine myomas.

机译：促性腺激素释放激素类似物治疗的子宫肌瘤妇女的临床反应，血管变化和血管生成。

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OBJECTIVE: Basic fibroblast growth factor (bFGF), vascular endothelial growth factor (VEGF), and platelet-derived growth factor (PDGF) are involved in the pathogenesis of leiomyomas and influence angiogenesis, which is necessary for growth of leiomyomas. Gonadotropin-releasing hormone analogue (GnRH-a) treatment might modify the growth factor expression and the blood supply in myomas. We investigated the effects of GnRH-a treatment on some clinical parameters, on the immunohistochemical expression of bFGF, VEGF, and PDGF, and on the vasculature of leiomyomas. METHODS: Thirty-one women were treated with leuprolide acetate for 3 months; 55 untreated patients formed the control group. Hematologic parameters were assessed at the admission, after GnRH-a treatment, and after surgery. Uterine volume was evaluated by ultrasonography. The immunoexpression of bFGF, VEGF, and PDGF and of the endothelial markers CD34 and CD105, as well as the vascular pattern, were studied in leiomyomas, comparing treated and untreated patients. RESULTS: Hematologic parameters improved and uterine volumes decreased after GnRH-a treatment. The immunoexpression of bFGF, VEGF, and PDGF decreased in treated myomas, together with the total number of vessels and the angiogenetic vessels. CONCLUSION: This study confirms the clinical response of uterine shrinkage after GnRH-a treatment. A pathogenetic role of bFGF, VEGF, and PDGF in myoma growth and vascularization is suggested. Finally, this study indirectly confirms the importance of the vasculature in leiomyoma growth.
机译：目的：碱性成纤维细胞生长因子（bFGF），血管内皮生长因子（VEGF）和血小板源性生长因子（PDGF）参与平滑肌瘤的发病机制并影响血管生成，这是平滑肌瘤生长所必需的。促性腺激素释放激素类似物（GnRH-a）的治疗可能会改变肌瘤中生长因子的表达和血液供应。我们研究了GnRH-a治疗对某些临床参数，bFGF，VEGF和PDGF的免疫组织化学表达以及平滑肌瘤的脉管系统的影响。方法：31例妇女接受醋酸亮丙瑞林治疗3个月。对照组为55名未经治疗的患者。在入院时，GnRH-a治疗后和手术后评估血液学参数。子宫体积通过超声检查评估。在平滑肌瘤中研究了bFGF，VEGF和PDGF的免疫表达以及内皮标记物CD34和CD105的免疫表达以及血管模式，比较了治疗和未治疗的患者。结果：GnRH-a治疗后血液学参数改善，子宫体积减少。在治疗的肌瘤中，bFGF，VEGF和PDGF的免疫表达以及血管和血管生成血管的总数均下降。结论：本研究证实了GnRH-a治疗后子宫缩小的临床反应。提示bFGF，VEGF和PDGF在肌瘤生长和血管形成中具有致病作用。最后，这项研究间接证实了脉管系统在平滑肌瘤生长中的重要性。

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