Synthesis of N-acetyl pyrazole and its analogues

Reddy H. Raveendranatha; Aggile Kadirappa; Subashini R.

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Synthesis of N-acetyl pyrazole and its analogues

机译：N-乙酰基吡唑及其类似物的合成

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Chalcones have been very attractive starting compounds in organic chemistry, as they are easy to synthesize with large variability. Chalcones are synthesized by Claisen-Schmidt condensation, which involves cross aldol condensation of suitable aldehydes and ketones by base catalysed or acid catalysed reactions followed by dehydration. So our aim is to construct novel N-acetyl pyrazole derivatives 4,5-dihydropyrazole were synthesized starting from alpha,beta-unsaturated ketones under the effect of hydrazine hydrate and phenyl hydrazine. After purification of the target molecules, they were confirmed by various characterization techniques like FT-IR, H-1 NMR, C-13 NMR and GC-MS analysis.

机译：查耳酮在有机化学中是非常有吸引力的起始化合物，因为它们易于合成且变异性很大。查尔酮是通过Claisen-Schmidt缩合反应合成的，Claisen-Schmidt缩合反应包括通过碱催化或酸催化反应，然后进行脱水，使合适的醛和酮进行交叉羟醛缩合。因此，我们的目的是在水合肼和苯基肼的作用下，以α，β-不饱和酮为原料，合成新的N-乙酰基吡唑衍生物4,5-二氢吡唑。纯化目标分子后，可通过多种表征技术（例如FT-IR，H-1 NMR，C-13 NMR和GC-MS分析）对其进行确认。

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《Journal of the Indian Chemical Society》 |2015年第6期|共4页
作者
Reddy H. Raveendranatha; Aggile Kadirappa; Subashini R.;
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正文语种 eng
中图分类化学;
关键词
Chalcones; grinding; hydrazine hydrate; pyrazoles;

机译：查耳酮;研磨;水合肼;吡唑;

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Synthesis of N-acetyl pyrazole and its analogues

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