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首页> 外文期刊>Journal of the Indian Medical Association. >A hospital-based study on pulmonary function tests and exercise tolerance in patients of chronic obstructive pulmonary disease and other diseases.
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A hospital-based study on pulmonary function tests and exercise tolerance in patients of chronic obstructive pulmonary disease and other diseases.

机译：一项基于医院的慢性阻塞性肺疾病和其他疾病患者肺功能测试和运动耐量的研究。

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A total of 105 male and 60 female patients were screened in the respiratory medicine outpatients' department, Institute of Postgraduate Medical Education & Research, Kolkata between December, 2002 and January, 2005. Chronic obstructive pulmonary disease patients were diagnosed on the basis of history and clinical examination while patients with body mass index > or =25 and otherwise disease-free were grouped as overweights. Patients suffering from other diseases like systemic hypertension, etc, were referred from other departments after proper evaluation. The patients and controls (n=10) each for male and female groups were subjected to spirometry using computerised electronic spirometer while exercise tolerance was evaluated by modified Harvard step test. Thirty-nine male and 21 female patients were diagnosed and grouped in chronic obstructive pulmonary disease group. Both purely obstructive [forced expiratory volume in 1 second (FEV1)/forced vital capacity (FVC)% pred<70 and reduced FEV1% pred] and mixed (both obstructive and restrictive pattern ie, FEV1/FVC% pred normal or supernormal, FVC% pred <80 indicating restrictive pattern and forced expiratory flow between 25% and 75% of the vital capacity (FEF(25-75)) pred or peak expiratory flow rate (PEFR)% pred <70 indicating early small airway obstruction pattern were seen in both sexes. Although the exercise tolerance values were non-significant in both sexes in chronic obstructive pulmonary disease obstructive pattern group, in mixed pattern group it was seen significant reduction compared to control. Hypertensives (21 males and 7 females) showed obstructive spirometric pattern. Exercise tolerance values were significantly reduced compared to controls. Male overweights (n=13) showed restrictive pattern while female overweights (n=8) showed obstructive pattern in spirometry. Exercise tolerance values were non-significant compared to control in both the groups. In ischaemic heart disease patients (n=6) FEV1%pred showed significant reduction in spirometry. In patients suffering from type 2 diabetes mellitus (n=4), post-tuberculous group (n=7), hypothyroid (n=6), collagen vascular disease group (n=6) showed restrictive spirometric pattern and the above groups including IHD patients showed significant reduction in exercise tolerance values. Some authors have stated that mixed ventilatory defect is characterised by low FEV1/FVC% pred in spirometry and low lung volumes where the lung volumes have to be ascertained by other methods but in the present investigation it was observed that mixed ventilatory defect can be estimated by spirometry; PEFR and/or FEF(25-75%). pred <70% whereas FEV1/FVC% pred is normal or supernormal. This finding is completely new one to predict mixed ventilatory defect.
机译：在2002年12月至2005年1月之间，在加尔各答研究生医学教育与研究学院的呼吸内科门诊中对105例男性和60例女性患者进行了筛查。根据病史和病史诊断为慢性阻塞性肺疾病患者体重指数≥25且无其他疾病的患者的临床检查被归类为超重。经适当评估后，将其他系统性高血压等疾病患者转诊至其他部门。男性和女性组的患者和对照组（n = 10）均使用计算机电子肺活量计进行肺活量测定，同时通过改良的哈佛阶梯试验评估运动耐力。确诊为慢性阻塞性肺疾病组的男39例，女21例。纯粹阻塞性[1秒内呼气量（FEV1）/强制肺活量（FVC）％pred <70和FEV1％pred降低]和混合（阻塞性和限制性模式，即FEV1 / FVC％pred正常或超常，FVC ％pred <80表示限制性模式，强制呼气流量在肺活量（FEF（25-75））pred的25％至75％之间，或峰值呼气流速（PEFR）％pred <70表示早期出现小气道阻塞模式在慢性阻塞性肺疾病阻塞模式组中，尽管男女的运动耐力值均无统计学意义，但在混合模式组中，与对照组相比，运动容忍度明显降低;高血压患者（男性21例，女性7例）表现出阻塞性肺功能。与对照组相比，运动耐量值显着降低，男性超重（n = 13）表现出限制性模式，女性超重（n = 8）表现出阻塞性肺功能测定。与两组相比，对照组均无统计学意义。在缺血性心脏病患者（n = 6）中，FEV1％pred显示肺活量显着降低。在患有2型糖尿病的患者中（n = 4），结核后组（n = 7），甲状腺功能减退（n = 6），胶原蛋白血管病组（n = 6）表现出限制性肺功能检查模式，上述各组包括IHD患者的运动耐量值显着降低。一些作者指出，混合通气缺陷的特征是肺活量测定中FEV1 / FVC％偏低，肺体积低，必须通过其他方法确定肺体积，但在本研究中，观察到混合通气缺陷可以通过肺量计PEFR和/或FEF（25-75％）。 pred <70％，而FEV1 / FVC％pred正常或超常。这一发现是预测混合通气缺陷的全新发现。

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