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首页> 外文期刊>Journal of Theoretical Biology >Are the local adjustments of the relative spatial frequencies of the dynein arms and the beta-tubulin monomers involved in the regulation of the '9+2' axoneme?
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Are the local adjustments of the relative spatial frequencies of the dynein arms and the beta-tubulin monomers involved in the regulation of the '9+2' axoneme?

机译：动力蛋白和β-微管蛋白单体相对空间频率的局部调节是否参与了“ 9 + 2”轴突蛋白的调控？

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摘要

The "9+2" axoneme is a highly specific cylindrical machine whose periodic bending is due to the cumulative shear of its 9 outer doublets of microtubules. Because of the discrete architecture of the tubulin monomers and the active appendices that the outer doublets carry (dynein arms, nexin links and radial spokes), this movement corresponds to the relative shear of these topological verniers, whose characteristics depend on the geometry of the wave train. When an axonemal segment bends, this induces the compressed and dilated conformations of the tubulin monomers and, consequently, the modification of the spatial frequencies of the appendages that the outer doublets carry. From a dynamic point of view, the adjustments of the spatial frequencies of the elements of the two facing verniers that must interact create different longitudinal periodic patterns of distribution of the joint probability of the molecular interaction as a function of the location of the doublet pairs around the axonemal cylinder and their spatial orientation within the axonemal cylinder. During the shear, these patterns move along the outer doublet intervals at a speed that ranges from one to more than a thousand times that of sliding, in two opposite directions along the two opposite halves of the axoneme separated by the bending plane, respecting the polarity of the dynein arms within the axoneme. Consequently, these waves might be involved in the regulation of the alternating activity of the dynein arms along the flagellum, because they induce the necessary intermolecular dialog along the axoneme since they could be an element of the local dynamic stability/instability equilibrium of the axoneme. This complements the geometric clutch model [Lindemann, C., 1994. A "geometric clutch" hypothesis to explain oscillations of the axoneme of cilia and flagella. J. Theor. Biol. 168, 175-189].
机译：“ 9 + 2”轴突是一种高度特殊的圆筒形机器，其周期性弯曲是由于其9个微管外部双峰的累积剪切所致。由于微管蛋白单体的离散结构以及外部双峰所携带的活性附件（动力蛋白臂，神经连接和放射状辐条），这种运动对应于这些拓扑游标的相对剪切，其特性取决于波的几何形状培养。当轴突节段弯曲时，这会引起微管蛋白单体的压缩和扩张构象，并因此导致外部双峰所携带的附属物的空间频率改变。从动态的角度来看，必须相互作用的两个面对游标的元素的空间频率的调整产生了分子相互作用的联合概率的分布的不同的纵向周期性分布，该分布是双峰对周围位置的函数轴突圆柱体及其在轴突圆柱体内的空间方向。在剪切过程中，这些模式沿着外部双峰间隔以滑动的一倍到一千倍的速度移动，沿两个相反的方向沿着被弯曲平面分开的轴突的两个相对的两半移动轴突内的达因臂。因此，这些波可能参与了鞭毛中达因臂的交替活动的调节，因为它们会沿着轴突诱导必要的分子间对话，因为它们可能是轴突局部动态稳定性/不稳定性平衡的一个要素。这补充了几何离合模型[Lindemann，C.，1994。“几何离合”假说可解释纤毛和鞭毛轴突的振荡。 J.理论。生物学168，175-189]。

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