...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of toxicology-Clinical toxicology >Zuclopenthixol-induced neuroleptic malignant syndrome in an adolescent girl
【24h】

Zuclopenthixol-induced neuroleptic malignant syndrome in an adolescent girl

机译：Zuclopenthixol诱导的青春期恶性精神病综合症

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

We present the case of a 14-year-old female who had many characteristics of neuroleptic malignant syndrome (NMS) without pyrexia following a single depot injection of 200 mg of zuclopenthixol. The patient presented with a change in mental status that had progressed over the preceding 48 hours. Subsequently, she became increasingly agitated and confused, and developed diffuse muscular rigidity, mutism, tremor, tachycardia, diaphoresis, sialorrhea, and incontinence. Results of laboratory tests showed elevated CPK levels, leukocytosis, and a low serum iron level. Bromocriptine and diazepam were used as initial treatment of a probable NMS and provided significant improvement. During the next seven days, she clinically improved but continued to exhibit emotional lability, logorrhea, elevated mood, and increased psychomotor activity. Therefore, bromocriptine and diazepam were discontinued and lorazepam and lithium were administered as treatment of a bipolar disorder. Four weeks later, she was discharged in stable condition. The presentation of this case report suggests that the primary psychiatric diagnosis is important in antipsychotic usage in the pediatric population, and that young patients receiving neuroleptic treatment should be monitored for the early signs of NMS. Using the diagnostic criteria of a neuroleptic toxicity spectrum may result in greater clinical awareness and earlier recognition of NMS.
机译：我们介绍了一个14岁女性的案例，该女性在单次储库注射200 mg的zuclopenthixol后，就具有许多精神过敏性恶性综合征（NMS）且没有发热的特征。患者出现了在过去48小时内进展的精神状态变化。随后，她变得越来越烦躁和困惑，并发展为弥漫性的肌肉僵硬，默，震颤，心动过速，发汗，腹泻和失禁。实验室测试结果显示CPK水平升高，白细胞增多和血清铁水平低。溴隐亭和地西epa被用作可能的NMS的初始治疗，并提供了明显的改善。在接下来的7天里，她的临床状况有所好转，但仍表现出情绪不稳，无痛，情绪升高和精神运动活动增加。因此，停用溴隐亭和地西epa，并给予劳拉西m和锂来治疗双相情感障碍。四周后，她出院情况稳定。该病例报告的提出表明，在儿科人群中抗精神病药的使用对主要精神病学诊断很重要，应监测接受抗精神病药治疗的年轻患者的NMS早期征象。使用抗精神病药毒性光谱的诊断标准可能会导致更高的临床意识和对NMS的更早认识。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号