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首页> 外文期刊>Journal of toxicology-Clinical toxicology >The effects of lithium, valproic acid, and carbamazepine during pregnancy and lactation.
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The effects of lithium, valproic acid, and carbamazepine during pregnancy and lactation.

机译：锂，丙戊酸和卡马西平在怀孕和哺乳期的影响。

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The chronic, complex, and episodic course of bipolar mood disorder presents a particularly formidable challenge to the clinician making a treatment plan for the onset or recurrence of the illness during pregnancy and lactation. Women treated with anti-manic drugs who become pregnant are commonly considered to be at high risk for fetal complications during the pregnancy or during lactation. The risks of antimanic drug use during pregnancy include teratogenic effects, direct neonatal toxicity, and the potential for longer-term neurobehavioral sequela. The use of medications during pregnancy and lactation requires critical attention to the timing of exposure, dosage, duration of use, and fetal susceptibility. The postnatal period is a time of increased onset and relapse of mental illness. No antimanic drug can be proven completely safe. Prescribing antimanic medications with a long safety record, avoiding exposure in the first trimester; avoiding multidrug regimens, and prescribing the lowest dose for the shortest duration will minimize the fetal risk. This review considers treatment with lithium, valproic acid, and carbamazepine. It assesses the risk to the fetus, the perinatal risks for the infant, the risks associated with treatment during the puerperium and breast-feeding, and the risks to the later development of the child.
机译：躁郁症的慢性，复杂和发作性过程给临床医生提出了在怀孕和哺乳期间疾病发作或复发的治疗计划方面的特别艰巨的挑战。通常认为使用抗躁狂药治疗的妇女在怀孕或哺乳期间发生胎儿并发症的风险很高。怀孕期间使用抗躁狂药的风险包括致畸作用，直接的新生儿毒性以及长期神经行为后遗症的可能性。在怀孕和哺乳期间使用药物需要特别注意接触时间，剂量，使用时间和胎儿易感性。产后时期是精神疾病发作和复发的时期。没有抗躁狂药可以被证明是完全安全的。开具长期安全记录的抗躁狂药处方，避免在孕早期暴露;避免使用多种药物，并在最短的时间内开出最低剂量，将胎儿的风险降到最低。该评价考虑使用锂，丙戊酸和卡马西平治疗。它评估对胎儿的风险，对婴儿的围产期风险，在产褥期和母乳喂养期间与治疗相关的风险以及对儿童后期发育的风险。

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