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首页> 外文期刊>Journal of Trace Elements in Experimental Medicine >Impact of Mechanical Vascular Injury on Whole Blood and Plasma Concentrations of Trace Elements and Electrolytes in Patients With Coronary Heart Disease
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Impact of Mechanical Vascular Injury on Whole Blood and Plasma Concentrations of Trace Elements and Electrolytes in Patients With Coronary Heart Disease

机译：机械性血管损伤对冠心病患者全血和血浆中微量元素和电解质的浓度的影响

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摘要

Concentrations of the seven trace elements-cobalt (Co), cesium (Cs), copper (Cu), lead (Pb), rubidium (Rb), strontium (Sr), and zinc (Zn)-were determined in 76 whole blood and 76 plasma samples of patients with coronary heart disease undergoing percutaneous trans-luminal coronary angioplasty (PTCA) by inductively coupled plasma mass spectrometry. Additionally, concentrations of iron (Fe) and the electrolytes sodium (Na), potassium (K), magnesium (Mg), and calcium (Ca) in the plasma of these patients were determined, To investigate the impact of PTCA on the concentrations of these elements, blood and plasma samples were collected 4-12 hours prior to (n = 16) and 24-30 hours after (n = 60) the clinical intervention. Concentrations for Rb and Cs in whole blood and plasma decreased after PTCA, but remained within the normal ranges reported for healthy adults. Concentrations of Co in whole blood and plasma were higher than the reported reference ranges and decreased significantly (P < 0,0001) in the plasma after the clinical intervention. Plasma Fe prior to PTCA was in the middle of the reference range and decreased significantly (P < 0,001) after PTCA to the very low end of the normal range. All blood Cu concentrations were at the lower end of the normal range and did not change during the clinical intervention. Concentrations of all other elements in the plasma and whole blood of our patients were within the normal ranges for healthy adults and remained unchanged
机译：在76个全血中，测定了钴（Co），铯（Cs），铜（Cu），铅（Pb），rub（Rb），锶（Sr）和锌（Zn）等七个微量元素的浓度。通过电感耦合等离子体质谱法对76位接受过经皮腔内冠状动脉成形术（PTCA）的冠心病患者的血浆样品进行分析。此外，测定了这些患者血浆中铁（Fe）以及电解质钠（Na），钾（K），镁（Mg）和钙（Ca）的浓度，以研究PTCA对血红蛋白浓度的影响。在临床干预之前（n = 16）4-12小时（n = 60）之后（n = 60）24-30小时收集这些元素，血液和血浆样本。 PTCA后，全血和血浆中Rb和Cs的浓度降低，但仍保持在健康成年人报告的正常范围内。临床干预后，全血和血浆中的Co浓度高于报告的参考范围，血浆中的Co浓度显着降低（P <0,0001）。 PTCA之前的血浆Fe处于参考范围的中间，而PTCA之后的血浆Fe显着降低（P <0,001）至正常范围的极低端。所有血中铜的浓度都在正常范围的下限，并且在临床干预期间没有变化。我们患者血浆和全血中所有其他元素的浓度在健康成年人的正常范围内，并保持不变

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