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首页> 外文期刊>Journal of Veterinary Diagnostic Investigation >Canine ovarian tumors: an immunohistochemical study with HBME-1 antibody.
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Canine ovarian tumors: an immunohistochemical study with HBME-1 antibody.

机译：犬卵巢肿瘤：HBME-1抗体的免疫组织化学研究。

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摘要

The morphology of ovarian tumors is characterized by a variety of histological features causing diagnostic difficulties. In human medicine, HBME-1 (Hector Battifora mesothelial epitope)-1 is one of the immunohistochemical markers employed in the diagnosis of ovarian epithelial tumors. The aim of the current study was to investigate the reliability of the marker HBME-1 in canine ovaries, granulosa cell tumors, and epithelial ovarian neoplasms to determine whether this marker could be included in an immunohistochemical panel for differential diagnoses of canine ovarian tumors. Samples were obtained from 4 normal ovaries, 10 granulosa cell tumors, and 18 epithelial ovarian tumors. After formalin fixation and paraffin embedding, tissue sections were stained with hematoxylin and eosin and probed immunohistochemically for the HBME-1 marker. Granulosa cells and related tumors were consistently negative for HBME-1. Normal ovarian surface epithelium and 17 out of 18 ovarian epithelial tumors were positive for HBME-1. The results suggested that HBME-1 would be a useful marker for the differential diagnosis of ovarian tumors in the dog.
机译：卵巢肿瘤的形态学特征是引起诊断困难的多种组织学特征。在人类医学中，HBME-1（Hector Battifora间皮表位）-1是用于诊断卵巢上皮肿瘤的免疫组化标记物之一。本研究的目的是研究标记物HBME-1在犬卵巢，颗粒细胞瘤和上皮性卵巢肿瘤中的可靠性，以确定该标记物是否可以包含在免疫组化法中以鉴别诊断犬卵巢肿瘤。从4个正常卵巢，10个颗粒细胞瘤和18个上皮性卵巢肿瘤获得样品。福尔马林固定和石蜡包埋后，将组织切片用苏木精和曙红染色，并用免疫组织化学方法检测HBME-1标记物。颗粒细胞和相关肿瘤始终为HBME-1阴性。正常卵巢表面上皮和18个卵巢上皮肿瘤中的17个为HBME-1阳性。结果表明，HBME-1将成为鉴别卵巢中卵巢肿瘤的有用标志物。

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