...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of Veterinary Internal Medicine >Thromboelastographic evaluation of hemostatic function in dogs with disseminated intravascular coagulation.
【24h】

Thromboelastographic evaluation of hemostatic function in dogs with disseminated intravascular coagulation.

机译：血栓弹力图评估犬弥散性血管内凝血的止血功能。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Background: There is considerable variation in the coagulation profile of dogs with disseminated intravascular coagulation (DIC), making it difficult to assess overall hemostatic function. Objectives: To characterize the overall hemostatic state in dogs with DIC, by use of tissue factor-activated thromboelastography (TF-TEG), and to determine whether there is an association between hemostasis and outcome. Animals: 50 dogs with DIC. Methods: Dogs admitted to the intensive care units, with an underlying disease known to predispose to DIC, were prospectively assessed with TF-TEG. Citrated blood samples were collected daily during hospitalization and an extended coagulation panel and TF-TEG were performed. Diagnosis of DIC was based on expert opinion. Results: Hemostatic dysfunction was observed on the TF-TEG profile in 33/50 of the dogs, of which 22/50 were hypercoagulable and 11/50 were hypocoagulable based on the TF-TEG G value alone. There were significant differences in k, alpha , and MA values (P<.0001) among hypo-, normo-, and hypercoagulable dogs. There was a significant difference in case fatality rate between hypo- (64%) and hypercoagulable (32%) dogs (relative risk=2.38; P=.04). Dogs that died had significantly lower antithrombin activity (P=.03) and higher d-dimer concentration (P=.03) than survivors. Conclusions: The most common overall hemostatic abnormality in dogs diagnosed with DIC was hypercoagulability, and there was significant difference in survival between hyper- and hypocoagulable dogs. The results suggest TF-TEG is valuable in the assessment of hemostatic function in dogs diagnosed with DIC.
机译：背景：弥散性血管内凝血（DIC）的狗的凝血曲线存在很大差异，因此难以评估总体止血功能。目的：通过使用组织因子激活的血栓弹性成像（TF-TEG）来表征DIC犬的总体止血状态，并确定止血与预后之间是否存在关联。动物：50只DIC狗。方法：使用TF-TEG对进入重症监护病房的犬患已知患有DIC的潜在疾病进行前瞻性评估。住院期间每天收集柠檬酸血样，并进行扩展凝血和TF-TEG。 DIC的诊断基于专家意见。结果：在33/50的狗中，在TF-TEG谱上观察到止血功能障碍，仅基于TF-TEG G值，其中22/50为高凝性，而11/50为低凝性。低凝，正常和高凝狗之间的k，alpha和MA值存在显着差异（P <.0001）。低（64％）和高凝（32％）狗的病死率有显着差异（相对危险度= 2.38; P = .04）。与存活者相比，死亡的狗具有明显更低的抗凝血酶活性（P = .03）和更高的d-二聚体浓度（P = .03）。结论：诊断为DIC的犬中最常见的总体止血异常是高凝性，高凝和低凝狗之间的生存率存在显着差异。结果表明，TF-TEG对诊断为DIC的犬的止血功能具有重要价值。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号