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首页> 外文期刊>Journal of vascular and interventional radiology: JVIR >Safety and therapeutic efficacy of complete or near-complete ablation of symptomatic uterine fibroid tumors by MR imaging-guided high-intensity focused US Therapy
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Safety and therapeutic efficacy of complete or near-complete ablation of symptomatic uterine fibroid tumors by MR imaging-guided high-intensity focused US Therapy

机译：MR成像引导的高强度聚焦美国疗法对症状性子宫肌瘤的完全或接近完全消融的安全性和疗效

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Purpose To evaluate the safety and therapeutic efficacy of magnetic resonance (MR) imaging-guided high-intensity focused ultrasound (US) ablation of symptomatic uterine fibroid tumors with an immediate nonperfused volume (NPV) ratio of 80% or more. Materials and Methods A total of 79 women with 117 uterine tumors were treated with MR-guided high-intensity focused US ablation. Immediate NPV, complications, and therapeutic efficacy (tumor volume reduction ratio and symptom severity score [SSS] decrease at 3-mo follow-up) were retrospectively assessed. Statistical comparisons of the frequency of complications and therapeutic efficacy were performed between patients with NPV ratios of at least 80% and less than 80%. Results Technical success was achieved in 93.7% of cases (n = 74) of cases, and the immediate NPV ratio was 62.7% ± 25.5. Twenty-four patients exhibited an NPV ratio of at least 80% (89.7% ± 5.8), and 50 patients showed an NPV ratio of less than 80% (49.8% ± 20.7). All complications were minor in severity, and the incidences were not significantly different between groups (P >.05). The 3-month volume reduction ratio was significantly greater in patients with an NPV ratio of at least 80% (0.43 ± 0.17) than in those with an NPV ratio of less than 80% (0.20 ± 0.26; P =.002), although the decreases in SSS were not significantly different (20.9 ± 19.6 vs 12.1 ± 10.1; P =.097). Conclusions In MR-guided high-intensity focused US ablation of symptomatic uterine fibroid tumors, achievement of an immediate NPV ratio of at least 80% is safe, with greater tumor volume shrinkage compared with cases with a lower NPV ratio.
机译：目的评估有症状的子宫肌瘤肿瘤的磁共振（MR）成像引导的高强度聚焦超声（US）消融治疗的安全性和治疗效果，即刻非灌注体积（NPV）比率为80％或更高。材料和方法总共79例117例子宫肿瘤的女性接受了MR引导的高强度聚焦超声消融治疗。回顾性评估了立即NPV，并发症和治疗效果（在3个月的随访中肿瘤体积减少率和症状严重程度评分[SSS]降低）。在NPV比率至少为80％且小于80％的患者之间进行并发症发生频率和治疗效果的统计比较。结果93.7％（n = 74）的病例获得技术成功，即时净现值比为62.7％±25.5。 24例患者的NPV比率至少为80％（89.7％±5.8），50例患者的NPV比率小于80％（49.8％±20.7）。所有并发症的严重程度均较小，各组之间的发生率无显着差异（P> .05）。 NPV比率至少为80％（0.43±0.17）的患者的3个月容积减少率显着高于NPV比率小于80％（0.20±0.26; P = .002）的患者。 SSS的降低没有显着差异（20.9±19.6和12.1±10.1; P = .097）。结论在有症状的子宫肌瘤的MR引导下高强度聚焦超声消融中，与NPV较低的病例相比，即时NPV至少达到80％是安全的，肿瘤体积缩小更大。

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