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首页> 外文期刊>Journal of Veterinary Science >Canine model of ischemic stroke with permanent middle cerebral artery occlusion: clinical features, magnetic resonance imaging, histopathology, and immunohistochemistry
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Canine model of ischemic stroke with permanent middle cerebral artery occlusion: clinical features, magnetic resonance imaging, histopathology, and immunohistochemistry

机译：患有永久性大脑中动脉阻塞的缺血性中风的犬模型：临床特征，磁共振成像，组织病理学和免疫组化

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摘要

The purpose of this study was to identify time-related changes in clinical, MRI histopathologic, and immunohistochemical findings associated with ischemic stroke in dogs. Additionally, the association of cerebrospinal fluid (CSF) and tissue levels of interleukin (IL)-6 with clinical prognosis was assessed. Ischemic stroke was induced by permanent middle cerebral artery occlusion (MCAO) in nine healthy experimental dogs. The dogs were divided into three groups according to survival time and duration of the experimental period: group A (survived only 1 day), group B (1-week experimental period), and group C (2-week experimental period). Neurologic status was evaluated daily. Magnetic resonance imaging (MRI) was performed according to a predetermined schedule. Concentration of IL-6 in CSF was measured serially after ischemic stroke. Postmortem examination was performed for all experimental dogs. During histopathological examination, variable degrees of cavitation and necrosis due to neuronal cytopathic effects, such as pyknotic nuclei and cytoplasmic shrinkage, were observed on the affected side of the cerebral cortex in all dogs Immunohistochemistry specific for IL-6 showed increased expression in the ischemic lesions. CSF IL-6 concentrations and ischemic lesion volumes 1 day after ischemic stroke were significantly higher in group A compared to groups B and C.
机译：这项研究的目的是确定与狗缺血性卒中相关的临床，MRI组织病理学和免疫组织化学结果与时间相关的变化。此外，评估了脑脊液（CSF）和白细胞介素（IL）-6的组织水平与临床预后的关系。永久性大脑中动脉闭塞（MCAO）诱发了九只健康实验犬的缺血性中风。根据存活时间和实验期的持续时间将狗分为三组：A组（仅存活1天），B组（1周实验期）和C组（2周实验期）。每天评估神经系统状况。根据预定的时间表进行磁共振成像（MRI）。缺血性中风后连续测量脑脊液中IL-6的浓度。对所有实验犬进行死后检查。在组织病理学检查期间，在所有狗的大脑皮层的患侧均观察到了由于神经元细胞病变作用（如致死性核和胞质萎缩）引起的不同程度的空化和坏死，IL-6特异性的免疫组织化学显示缺血性病变中表达增加。与B组和C组相比，A组缺血性卒中后1天的CSF IL-6浓度和缺血性病变体积显着更高。

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