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首页> 外文期刊>Diabetes technology & therapeutics >Continuous glucose monitoring reveals delayed nocturnal hypoglycemia after intermittent high-intensity exercise in nontrained patients with type 1 diabetes.
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Continuous glucose monitoring reveals delayed nocturnal hypoglycemia after intermittent high-intensity exercise in nontrained patients with type 1 diabetes.

机译：持续的血糖监测显示，在未经训练的1型糖尿病患者中，间歇性的高强度运动后，其夜间夜间血糖过低。

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摘要

OBJECTIVE: Exercise is a cornerstone of diabetes therapy in type 1 diabetes mellitus (DMT1) patients. The type of exercise is important in determining the propensity to hypoglycemia. We assessed, by continuous glucose monitoring (CGM), the glucose profiles during and in the following 20h after a session of two different types of exercise. RESEARCH DESIGN AND METHODS: Eight male volunteers with well-controlled DMT1 were studied. They underwent 30min of both intermittent high-intensity exercise (IHE) and moderate-intensity exercise (MOD) in random order. Expired air was recorded during exercise, while metabolic and hormonal determinations were performed before and for 120 min after exercises. The CGM system and activity monitor were applied for the subsequent 20h. RESULTS: Blood glucose level declined during both type of exercise. At 150 min following the start of exercise, plasma glucose content was slightly higher after IHE. No changes were observed in plasma insulin concentration. A significant increase of norepinephrine concentration was noticed during IHE. Between midnight and 6:00 a.m. the glucose levels were significantly lower after IHE than those observed after MOD (area under the curve, 23.3 +/- 3 vs. 16 +/- 3 mg/dL/420 min [P = 0.04]; mean glycemia at 3 a.m., 225 +/- 31 vs. 147 +/- 17 mg/dL [P<0.05]). The number of hypoglycemic episodes after IHE was higher than that observed after MOD (seven vs. two [P<0.05]). CONCLUSIONS: We demonstrate that (1) CGM is a useful approach in DMT1 patients who undergo an exercise program and (2) IHE is associated with delayed nocturnal hypoglycemia.
机译：目的：锻炼是1型糖尿病（DMT1）患者糖尿病治疗的基石。运动类型对于确定低血糖的倾向很重要。我们通过连续葡萄糖监测（CGM）评估了两种不同类型的运动训练期间以及之后20小时内的葡萄糖曲线。研究设计与方法：研究了8位DMT1控制良好的男性志愿者。他们以随机顺序进行了30分钟的间歇性高强度运动（IHE）和中强度运动（MOD）。运动过程中记录了呼出的空气，运动前和运动后120分钟进行了代谢和激素测定。随后的20小时应用了CGM系统和活动监视器。结果：两种运动期间血糖水平均下降。运动开始后150分钟，IHE后血浆葡萄糖含量略高。血浆胰岛素浓度未见变化。在IHE期间发现去甲肾上腺素浓度显着增加。在午夜至凌晨6:00之间，IHE后的血糖水平明显低于MOD后的血糖水平（曲线下面积，分别为23.3 +/- 3和16 +/- 3 mg / dL / 420分钟[P = 0.04];凌晨3点的平均血糖为225 +/- 31 vs.147 +/- 17 mg / dL [P <0.05]）。 IHE后的降血糖发作次数高于MOD后的降血糖发作次数（七对二[P <0.05]）。结论：我们证明（1）CGM是接受运动计划的DMT1患者的一种有用方法，（2）IHE与延迟性夜间低血糖有关。

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