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首页> 外文期刊>Diabetes/metabolism research and reviews >Diabetic foot disease: Impact of ulcer location on ulcer healing
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Diabetic foot disease: Impact of ulcer location on ulcer healing

机译：糖尿病足病：溃疡位置对溃疡愈合的影响

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Background: Healing of heel ulcers in patients with diabetes is considered to be poor, but there is relatively little information on the influence of ulcer location on ulcer healing. Methods: The influence of ulcer location on time to healing of diabetic foot ulcers was analysed by multivariate Cox regression analysis for 1000 patients included in the Eurodiale study, a prospective cohort study of patients with diabetic foot disease. Results: Median time to healing was 147days for toe ulcers [(95% confidence interval (CI) 135-159days)], 188days for midfoot ulcers (95% CI 158-218days) and 237days for heel ulcers (95% CI 205-269days) (p<0.01). The median time to healing for plantar ulcers was 172days (95% CI 157-187days) and 155days (95% CI 138-172days) for nonplantar ulcers (p=0.71). In multivariate Cox regression analysis, the hazard ratio for ulcer healing for midfoot and heel ulcers compared with toe ulcers was 0.77 (95% CI 0.64-0.92) and 0.62 (95% CI 0.47-0.83), respectively; the hazard ratio for ulcer healing for plantar versus nonplantar ulcers was 1 (95% CI 0.84-1.19). Other factors significantly influencing time to healing were the duration of diabetes, ulcer duration, the presence of heart failure and the presence of peripheral arterial disease. Conclusions: Time to ulcer healing increased progressively from toe to midfoot to heel, but did not differ between plantar and nonplantar ulcers. Our data also indicate that risk factors for longer time to healing differ from factors that affect the ultimate number of ulcers that heal (healing rate).
机译：背景：糖尿病患者的足跟溃疡愈合不良，但关于溃疡位置对溃疡愈合影响的信息相对较少。方法：采用多变量Cox回归分析方法，对Eurodiale研究中包括的1000例糖尿病足疾病患者进行前瞻性队列研究，分析溃疡位置对时间对糖尿病足溃疡愈合的影响。结果：足趾溃疡的中位治愈时间为147天[（95％置信区间（CI）135-159天）]，中足溃疡为188天（95％CI 158-218天），足跟溃疡为237天（95％CI 205-269天） ）（p <0.01）。足底溃疡的中位治愈时间为非足底溃疡的172天（95％CI 157-187天）和155天（95％CI 138-172天）（p = 0.71）。在多因素Cox回归分析中，与脚趾溃疡相比，中足和足跟溃疡溃疡愈合的危险比分别为0.77（95％CI 0.64-0.92）和0.62（95％CI 0.47-0.83）。足底溃疡与非足底溃疡溃疡愈合的危险比为1（95％CI 0.84-1.19）。显着影响治愈时间的其他因素是糖尿病的持续时间，溃疡的持续时间，心力衰竭的存在和周围动脉疾病的存在。结论：溃疡愈合时间从脚趾到脚中部到脚后跟逐渐增加，但足底和非足底溃疡之间没有差异。我们的数据还表明，较长时间治愈的危险因素与影响最终治愈的溃疡数（治愈率）的因素不同。

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