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首页> 外文期刊>Journal of interferon and cytokine research: The official journal of the International Society for Interferon and Cytokine Research >Interferon-induced upregulation and cytoplasmic localization of Myc-interacting protein Nmi.
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Interferon-induced upregulation and cytoplasmic localization of Myc-interacting protein Nmi.

机译：干扰素诱导的Myc相互作用蛋白Nmi的上调和细胞质定位。

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摘要

Nmi interacts with c-Myc, N-Myc, Max, and fos, as demonstrated by yeast two-hybrid and coimmunoprecipitation assays. Nmi is partially homologous to IFP 35, an interferon (IFN)-inducible protein. In this study, we show that basal expression of Nmi is upregulated by IFN in multiple tumor-derived cell lines. Treatment with IFN results in an increased amount of cytoplasmic Nmi distributed in a punctate granular pattern. We also demonstrate that Nmi is expressed in various fetal and adult tissues. As Nmi does not contain a known DNA-binding motif, it has the potential to form inactive heterodimers with its putative DNA-binding partners. Our studies suggest that Nmi may modulate its binding partners in an IFN-inducible manner.
机译：Nmi与c-Myc，N-Myc，Max和fos相互作用，如酵母双杂交和共免疫沉淀试验所证实。 Nmi与IFP 35（干扰素（IFN）诱导型蛋白）部分同源。在这项研究中，我们显示Nmi的基础表达在多种肿瘤来源的细胞系中被IFN上调。用IFN治疗导致呈点状颗粒状分布的细胞质Nmi增加。我们还证明了Nmi在各种胎儿和成人组织中表达。由于Nmi不包含已知的DNA结合基序，因此它有可能与假定的DNA结合伴侣形成无活性的异二聚体。我们的研究表明，Nmi可能以IFN诱导的方式调节其结合伴侣。

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