...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of interferon and cytokine research: The official journal of the International Society for Interferon and Cytokine Research >Orthodontic movement induces high numbers of cells expressing IFN-gamma at mRNA and protein levels.
【24h】

Orthodontic movement induces high numbers of cells expressing IFN-gamma at mRNA and protein levels.

机译：正畸运动可诱导大量在mRNA和蛋白质水平表达IFN-γ的细胞。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Cytokines are important signaling proteins that are liberated during immune challenges and exhibit many modulatory activities. However, their role in periodontal modeling during orthodontic tooth movement is not fully understood. The aim of this study was to analyze effects of mechanical force during orthodontic tooth movement, in the pressure zone, on the induction of interferon-gamma (IFN-gamma) as a proinflammatory cytokine of Th1 type and interleukin-4 (IL-4)/IL-10 as anti-inflammatory cytokines of Th2 type. In 12 Wistar rats 40-45 days old, the maxillary first molar was moved mesially by means of a closed coil spring for 3, 7, and 10 days. The contralateral side served as a control. IFN-gamma, IL-4, and IL-10 mRNA were determined by in situ, hybridization, and protein levels of IFN-gamma was measured by immunohistochemistry. Induction of IFN-gamma at both mRNA and protein levels was significantly higher on the experimental side than on the contralateral control side on day 3. The signal gradually became stronger on day 7 and remained high on day 10. Cytokines of the Th2 type (IL-4 and IL-10) were not detected at all examined time points in both pressure and contralateral control sides. Considering the potential immunoregulatory roles played by IFN-gamma, our data suggest that IFN-gamma may be involved in periodontium remodeling during orthodontic tooth movement.
机译：细胞因子是重要的信号蛋白，可在免疫攻击过程中释放并表现出许多调节活性。然而，它们在正畸牙齿运动期间在牙周模型中的作用尚未完全了解。这项研究的目的是分析正畸牙齿在压力区运动期间的机械力对诱导干扰素-γ（IFN-γ）作为Th1型和白介素-4（IL-4）促炎细胞因子的影响。 / IL-10作为Th2型抗炎细胞因子。在40-45天大的12只Wistar大鼠中，通过闭合的螺旋弹簧使上颌第一磨牙近中移动3、7和10天。对侧作为对照。通过原位，杂交确定IFN-γ，IL-4和IL-10 mRNA，并通过免疫组织化学测量IFN-γ的蛋白质水平。第3天，实验侧的IFN-γ诱导水平明显高于对侧对照侧。第7天，信号逐渐增强并在第10天保持高水平。Th2型细胞因子（IL）在压力和对侧对照侧的所有检查时间点均未检测到-4和IL-10）。考虑到IFN-γ发挥潜在的免疫调节作用，我们的数据表明IFN-γ可能与正畸牙齿移动过程中的牙周组织重塑有关。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号