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首页> 外文期刊>Journal of Surgical Oncology >Increased expression of HMGB1 is associated with poor prognosis in human bladder cancer
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Increased expression of HMGB1 is associated with poor prognosis in human bladder cancer

机译：HMGB1表达增加与人膀胱癌预后不良相关

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摘要

Background and Objective: High-mobility group box 1 (HMGB1) is a versatile protein with intranuclear and extracellular functions that is involved in numerous biological and pathological processes, such as transcription, DNA repair, and response to infection and inflammation. HMGB1 overexpression has been reported in a variety of human cancers. However, the clinical significance of HMGB1 expression in bladder cancer (BC) remains unclear. This study is aimed to investigate the correlations between HMGB1 expression and prognosis in patients with BC. Methods: HMGB1 protein expression in 164 primary BC tissue specimens was analyzed by immunohistochemistry, and its association with clinicopathologic factors and prognosis was also analyzed. Results: HMGB1 protein had high expression in 87 of 164 cases of BC (53%). HMGB1 overexpression was significantly associated with tumor grade (P < 0.001), and stage (P = 0.001). The Kaplan-Meier survival analysis demonstrated that HMGB1 expression was significantly associated with shorter disease-free survival and overall survival (both P < 0.001). Multivariate analysis further demonstrated that HMGB1 was an independent prognostic factor for patients with BC. Conclusions: HMGB1 might be a new molecular marker to predict the prognosis of patients with BC.
机译：背景与目的：高迁移率族蛋白1（HMGB1）是一种具有核内和细胞外功能的多功能蛋白，涉及许多生物学和病理学过程，例如转录，DNA修复以及对感染和炎症的反应。 HMGB1过表达已报道于多种人类癌症中。但是，HMGB1表达在膀胱癌（BC）中的临床意义仍不清楚。本研究旨在探讨HMGB1表达与BC患者预后之间的相关性。方法：采用免疫组织化学方法分析164例原发性BC组织标本中HMGB1蛋白的表达，并分析其与临床病理因素和预后的关系。结果：HMGB1蛋白在164例BC患者中有87个高表达（53％）。 HMGB1过表达与肿瘤分级（P <0.001）和分期（P = 0.001）显着相关。 Kaplan-Meier生存分析表明，HMGB1表达与较短的无病生存期和总生存期显着相关（均P <0.001）。多变量分析进一步表明，HMGB1是BC患者的独立预后因素。结论：HMGB1可能是预测BC患者预后的新的分子标志物。

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