...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Clinical and Experimental Immunology: An Official Journal of the British Society for Immunology >99th Dahlem conference on infection, inflammation and chronic inflammatory disorders: neonatal immune function and vaccine responses in children born in low-income versus high-income countries.
【24h】

99th Dahlem conference on infection, inflammation and chronic inflammatory disorders: neonatal immune function and vaccine responses in children born in low-income versus high-income countries.

机译：关于感染，炎症和慢性炎症性疾病的第99届达勒姆会议：低收入国家与高收入国家出生的儿童的新生儿免疫功能和疫苗反应。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

There is increasing evidence that the functional state of the immune system at birth is predictive of the kinetics of immune maturation in early infancy. Moreover, this maturation process can have a major impact on early vaccine responses and can be a key determinant of risk for communicable and non-communicable diseases in later life. We hypothesize that environmental and genetic factors that are often typical for poor-resource countries may have an important impact on prenatal immune development and predispose populations in low-income settings to different vaccine responses and disease risks, compared to those living in high-income countries. In this paper we aimed to summarize the major differences between neonatal and adult immune function and describe what is known so far about discrepancies in immune function between newborns in high- and low-income settings. Further, we discuss the need to test the immunological feasibility of accelerated vaccination schedules in high-risk populations and the potential of variation in disease specific and non-specific vaccine effects.
机译：越来越多的证据表明，出生时免疫系统的功能状态可预测婴儿早期免疫成熟的动力学。此外，这种成熟过程可能会对早期疫苗反应产生重大影响，并且可能成为决定晚年发生传染性和非传染性疾病风险的关键因素。我们假设资源贫乏国家通常常见的环境和遗传因素可能会对产前免疫发展产生重要影响，并使低收入人群与生活在高收入国家的人群相比，有不同的疫苗反应和疾病风险。在本文中，我们旨在总结新生儿和成人免疫功能之间的主要差异，并描述迄今为止在高收入和低收入环境下新生儿之间免疫功能差异的已知知识。此外，我们讨论了在高风险人群中测试加速疫苗接种计划的免疫学可行性以及疾病特异性和非特异性疫苗作用变化的可能性的需求。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号