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首页> 外文期刊>日本獣医師会雑誌 >Clinical evaluation of propionyl-promazine combined with either propofol, ketamine or thiopental as pre-medication and induction agents for canine inhalation anaesthesia.
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Clinical evaluation of propionyl-promazine combined with either propofol, ketamine or thiopental as pre-medication and induction agents for canine inhalation anaesthesia.

机译：丙酰丙嗪与丙泊酚，氯胺酮或硫喷妥钠作为犬吸入麻醉的前药和诱导剂的临床评价。

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摘要

Intravenous injections (IV) of propionyl-promazine (0.05 mg/kg) as premedication followed by IV injections of either propofol 6 mg/kg (group PRP-P, n=30); ketamine 5 mg/kg (group PRP-K, n=30); or thiopental 12.5 mg/kg (group PRP-T, n=30) as induction agents were carried out on 90 dogs. Anaesthesia was maintained by 50% nitrous oxide-50% oxygen-sevoflurane. The end-tidal concentration of sevoflurane during surgery ranged between 2.2 and 2.3% in PRP-P, between 2.0 and 2.1% in PRP-K, and between 1.9 and 2.1% in PRP-T, with no statistical difference among groups. In PRP-K, 7% of the dogs experienced transient convulsions after ketamine administration, and laryngeal reflex during intubations occurred in a high percentage (80%). Incidences of transient apnoea after intubation were 50% in PRP-P, 27% in PRP-K and 40% in PRP-T, respectively. During anaesthesia, because of such respiratory depression conditions as apnoea and hypercapnia, controlled ventilation was required in 9 dogs (30%) in PRP-P, 4 dogs (13%) in PRP-K and 10 dogs (33%) in PRP-T. Body temperature dropped with anaesthetic time. In all groups, heart rate remained stable at 120-135 bpm. Moderate treatable hypotension occurred in 5 dogs (17%) in PRP-P, 8 dogs (27%) in PRP-K and 5 dogs (17%) in PRP-T. Recovery from anaesthesia was quiet and smooth in all dogs except for PRP-T dogs. In conclusion, PRP-P, PRP-K, and PRP-T are useful in combinations for inhalation anaesthesia in clinically healthy dogs. But attention should be paid to the influence of laryngeal reflex and convulsion during induction with PRP-K and to delayed recovery when PRP-T is used.
机译：静脉内注射（IV）丙酰基丙嗪（0.05 mg / kg）作为处方药，然后静脉注射异丙酚6 mg / kg（PRP-P组，n = 30）;氯胺酮5 mg / kg（PRP-K组，n = 30）;在90只狗上进行了12.5 mg / kg硫喷妥钠（PRP-T组，n = 30）的诱导剂治疗。用50％一氧化二氮，50％氧气-七氟醚维持麻醉。术中七氟醚的潮气末浓度在PRP-P中介于2.2％至2.3％之间，在PRP-K中介于2.0％至2.1％之间，在PRP-T中介于1.9％至2.1％之间，各组之间无统计学差异。在PRP-K中，有7％的狗在服用氯胺酮后经历了短暂的惊厥，并且在插管过程中发生的喉反射率很高（80％）。插管后短暂性呼吸暂停的发生率在PRP-P中为50％，在PRP-K中为27％，在PRP-T中为40％。在麻醉期间，由于呼吸暂停状态如呼吸暂停和高碳酸血症，PRP-P的9只狗（30％），PRP-K的4只狗（13％）和PRP-K的10只狗（33％）需要控制通气T.体温随麻醉时间而下降。在所有组中，心率均稳定在120-135 bpm。可治疗的低血压发生在PRP-P的5只狗（17％），PRP-K的8只狗（27％）和PRP-T的5只狗（17％）中。除PRP-T犬外，所有犬从麻醉中恢复安静，通畅。总之，PRP-P，PRP-K和PRP-T可用于临床健康犬的吸入麻醉组合。但是，在使用PRP-K诱导时应注意喉反射和惊厥的影响，以及使用PRP-T时延迟恢复。

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