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首页> 外文期刊>日本兽医学杂誌 >Identification of a quantitative trait locus influencing plasma insulin levels after 70% pancreatectomy using the OLETF rat
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Identification of a quantitative trait locus influencing plasma insulin levels after 70% pancreatectomy using the OLETF rat

机译：使用OLETF大鼠鉴定在70％胰腺切除术后影响血浆胰岛素水平的定量性状基因座

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摘要

The Otsuka Long-Evans Tokushima Fatty (OLETF) rat is an animal model for obese-type non-insulin-dependent diabetes mellitus (NIDDM) in humans. The OLETF rat has poor capacity for proliferation of pancreatic #beta#-cells after partial pancreatectomy, which may be the critical pathogenetic event in NIDDM development. The poor pancreatic #beta#-cell proliferation in this model is characterized by reduction in #beta#-cell mass and decrease in insulin content in the remnant pancreas. Our investigation was designed to identify quantitative trait loci (QTLs) responsible for #beta#-cell mass and plasma insulin levels after partial pancreatectomy by performing a genome-wide scan in an F_2 intercross obtained by mating the OLETF and the Fischer-344 (F344) rats. We have identified a suggestive QTL for the plasma insulin levels, near D2OMgh5 on rat chromosome 20, with a maximum lod score of 3.75 which accounts for 20% of the total variance, while no QTLs were detected for #beta#-cell mass. This chromosome 20 QTL, whose OLETF allele is associated with low plasma insulin levels through acting in an incompletely recessive manner, may affect insulin secretion itself rather than #beta#-cell proliferation.
机译：Otsuka Long-Evans德岛肥胖（OLETF）大鼠是人类肥胖型非胰岛素依赖型糖尿病（NIDDM）的动物模型。 OLETF大鼠在部分胰腺切除术后胰腺＃beta＃细胞的增殖能力较弱，这可能是NIDDM发育中的关键致病事件。在该模型中不良的胰腺＃beta＃细胞增殖的特征在于＃beta＃细胞质量减少和残余胰腺中胰岛素含量的减少。我们的研究旨在通过对OLETF和Fischer-344（F344）交配获得的F_2杂交进行全基因组扫描，以鉴定部分胰腺切除术后＃beta＃-细胞质量和血浆胰岛素水平的定量性状位点（QTL） ）大鼠。我们已经确定了建议的血浆胰岛素水平的QTL，接近大鼠20号染色体上的D2OMgh5，最大lod得分为3.75，占总变异的20％，而未检测到＃beta＃细胞质量的QTL。该20号染色体QTL（其OLETF等位基因通过不完全隐性的方式与低血浆胰岛素水平相关联）可能影响胰岛素分泌本身，而不是＃beta＃细胞增殖。

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