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Effects of indomethacin on the selective release of follicle-stimulating hormone during the period of ovulation in the rat

机译：消炎痛对排卵期大鼠卵泡刺激素选择性释放的影响

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摘要

To determine whether indomethacin, a potent inhibitor of prostaglandins endoperoxide synthetase, affects the selective follicle-stimulating hormone (FSH) surge during the period of ovulation, the compound was administered intravenously (iv), concurrent with 10 IU human chorionic gonadotropin (hCG), to diestrous female rats at 16:00 hr. Indomethacin inhibited the number of ovulations in a dose-dependent manner, and treatment with 500 #mu#g indomethacin reduced number of oocytes in the ampullae most effectively without enteric lesions. In the histological observation, oocytes that had began to mature were found not only in unruptured luteinized follicles but also in ovarian interstitium beneath ruptured luteinized follicle. Despite the inhibitory effects of indomethacin on ovulation, peri-ovulatory FSH and progesterone surges occurred in comparable levels and duration to vehicle-treated animals. These results indicate that indomethacin-induced inhibition of prostaglandin synthesis does not affect the selective release of FSH during the peri-ovulatory period.
机译：为了确定吲哚美辛（一种有效的前列腺素内过氧化物合成酶抑制剂）是否在排卵期间影响选择性促卵泡激素（FSH）激增，静脉内给予该化合物（iv），同时配以10 IU人绒毛膜促性腺激素（hCG），在16:00时对雌性雌鼠进行攻击。消炎痛以剂量依赖性方式抑制排卵次数，用500＃mu＃g消炎痛治疗可最有效地减少壶腹卵母细胞数，且无肠道损害。在组织学观察中，不仅在未破裂的黄素化卵泡中发现卵母细胞，而且在破裂的黄素化卵泡下面的卵巢间质中也发现了卵母细胞。尽管消炎痛对排卵有抑制作用，但排卵周FSH和孕酮激增的发生水平和持续时间与溶媒治疗的动物相当。这些结果表明吲哚美辛诱导的前列腺素合成抑制作用不影响在排卵期FSH的选择性释放。

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