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The use of microarray technology for the analysis of Streptococcus pneumoniae

机译：微阵列技术在肺炎链球菌分析中的应用

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Streptococcus pneumoniae is an important human pathogen associated with pneumonia, septicaemia, meningitis and otitis media. It is estimated to result in 3 million child deaths worldwide every year and an even greater number of deaths among the elderly. Prior to the complete sequencing of the genomes of S. pneumoniae TIGR4 (serotype 4) and S. pneumoniae R6 (serotype 2), we designed a custom miniarray consisting of 497 pneumococcal genes. The overall objectives of our microarray investigations were, first, to assess the genetic diversity between different S. pneumoniae serotypes, clinical isolates and also different Streptococcus species; second, we aimed to use microarray technology to examine the mechanisms by which environmental factors influence pneumococcal gene expression, and ultimately to further the understanding of how these changes in gene expression are achieved and how they may alter the virulence of the organism.
机译：肺炎链球菌是与肺炎，败血病，脑膜炎和中耳炎有关的重要人类病原体。据估计，全世界每年造成300万儿童死亡，而老年人中的死亡人数甚至更高。在对肺炎链球菌TIGR4（血清型4）和肺炎链球菌R6（血清型2）的基因组进行完整测序之前，我们设计了由497个肺炎球菌基因组成的定制微阵列。我们微阵列研究的总体目标是，首先，评估不同肺炎链球菌血清型，临床分离株以及不同链球菌种之间的遗传多样性;其次，我们旨在使用微阵列技术来检查环境因素影响肺炎球菌基因表达的机制，并最终进一步了解基因表达的这些变化是如何实现的以及它们如何改变生物体的毒力。

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