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首页> 外文期刊>感染症学雑誌 >Evaluation of seven immunological assay reagents for hepatitis B virus surface antigen (HBsAg) in the sensitivity and the detection of HBsAg mutants
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Evaluation of seven immunological assay reagents for hepatitis B virus surface antigen (HBsAg) in the sensitivity and the detection of HBsAg mutants

机译：评估乙型肝炎病毒表面抗原（HBsAg）的七种免疫测定试剂对HBsAg突变体的敏感性和检测

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Mutants of hepatitis B virus surface antigen (HBsAg) are known as a cause of false-negative results in diagnostic tests for HBsAg; particularly when a diagnostic kit utilizes monoclonal antibodies to detect HBsAg. We compared seven HBsAg kits with regard to sensitivity for HBsAg subtypes (ad, ay) and their ability to detect nine different HBsAg mutants. Among them, the sensitivities of five kits were high and comparable to each other (0.2 - 0.3ng/ml). However, two kits were of lower sensitivity (0.8-1.3ng/ml, and 2.4-2.5ng/ml, respectively). Two kits, produced by the same company, reacted with all of the nine HBsAg mutants, but five kits showed false-negative results with one or more of the HBsAg mutants. These data indicate that there are differences in the detection sensitivities for HBsAg and abilities to detect HBsAg mutants among commercially available HBsAg kits, which may explain false-negative clinical results.
机译：乙型肝炎病毒表面抗原（HBsAg）的突变体被认为是HBsAg诊断测试中假阴性结果的原因。特别是当诊断试剂盒使用单克隆抗体检测HBsAg时。我们比较了七种HBsAg试剂盒的HBsAg亚型（ad，ay）敏感性以及检测九种不同HBsAg突变体的能力。其中，五种试剂盒的灵敏度很高，并且彼此相当（0.2-0.3ng / ml）。但是，两种试剂盒的灵敏度较低（分别为0.8-1.3ng / ml和2.4-2.5ng / ml）。同一家公司生产的两种试剂盒与所有九种HBsAg突变体都发生了反应，但是五种试剂盒对一个或多个HBsAg突变体显示了假阴性结果。这些数据表明，在市售的HBsAg试剂盒中，对HBsAg的检测敏感性和检测HBsAg突变体的能力存在差异，这可能解释了假阴性临床结果。

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