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Clinical utility of in situ hybridization for diagnosing respiratory tract infection and sepsis

机译：原位杂交在呼吸道感染和败血症诊断中的临床应用

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摘要

We studied the clinical utility of in situ hybridization (Hybrisep) in diagnosing respiratory infection and/ or sepsis. Peripheral blood was taken from patients with respiratory infections and suspected sepsis for both routine blood culture and in situ hybridization, and focal samples including sputum, bronchoalveolar lavage, and central and thoracic catheter, were simultaneously examined for bacterial culture. Specimens numbered 46. The clinical diagnosis was 20 cases of septicemia, with 26 specimens diagnosed as respiratory infectious diseases including hospital-acquired pneumonia and pleurisy. Positive cases of in situ hybridization were seen in 19 specimens (41.3%) in all specimens, significantly higher than that in blood culture (17.4%). Respiratory infection showed a high positive rate in in situ hybridization. Interestingly, the bacterial pathogen detected by in situ hybridization was not always consistent with that taken from focal samples. Whether the pathogen isolated by in situ hybridizationis accurate etiologically or diagnostically remains unknown, but our findings suggest a polymicrobial infection in patients with hospital-acquired respiratory infections. In situ hybridization thus provides important information on the etiological pathogen in different infectious diseases.
机译：我们研究了原位杂交（Hybrisep）在诊断呼吸道感染和/或败血症中的临床效用。从患有呼吸道感染和疑似脓毒症的患者中抽取外周血，用于常规血液培养和原位杂交，同时检查包括痰，支气管肺泡灌洗液，中央和胸腔导管在内的病灶样品的细菌培养。标本数量为46个。临床诊断为败血病20例，其中26个标本被诊断为呼吸道传染病，包括医院获得性肺炎和胸膜炎。在所有标本中，有19个标本（41.3％）可见到原位杂交的阳性病例，显着高于血液培养的标本（17.4％）。呼吸道感染在原位杂交中显示出高阳性率。有趣的是，通过原位杂交检测的细菌病原体并不总是与从病灶样品中获取的一致。通过原位杂交分离的病原体在病因上或诊断上是准确的还是未知的，但我们的发现表明医院获得性呼吸道感染的患者存在多微生物感染。因此，原位杂交提供了关于不同传染病中病原体的重要信息。

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