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首页> 外文期刊>Comparative Medicine >Acquired amegakaryocytic thrombocytopenia purpura in a rhesus macaque (Macaca mulatta).
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Acquired amegakaryocytic thrombocytopenia purpura in a rhesus macaque (Macaca mulatta).

机译：猕猴（猕猴）中获得的巨核细胞性血小板减少性紫癜。

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A 10-y-old multiparous rhesus macaque presented for an annual routine physical examination. Clinically, the animal had pale mucous membranes, petechial and ecchymotic hemorrhages in multiple sites, and a laceration at the tail base. Severe pancytopenia was noted on hematologic evaluation. The monkey was seronegative for SIV, simian T-lymphotropic virus, simian retrovirus type D, and Macacine herpesvirus 1. Bone marrow evaluation revealed a paucity of megakaryocytic precursors in a hypercellular marrow with marked erythroid hyperplasia. In light of these findings, the diagnosis was acquired amegakaryocytic thrombocytopenia purpura. Due to the poor prognosis of the syndrome and clinical deterioration of the monkey, euthanasia was elected. A definitive cause of the thrombocytopenia was not identified; however, the syndrome may have developed secondary to a recent spontaneous abortion. To our knowledge, this case represents the first reported observation of acquired amegakaryocytic thrombocytopenia purpura in a rhesus monkey.
机译：每年进行例行身体检查的10岁多胎猕猴。临床上，该动物粘膜苍白，多个部位出现瘀斑和瘀斑出血，尾基部有裂伤。血液学评估发现严重的全血细胞减少。这只猴子对SIV，猿猴T淋巴病毒，猿猴逆转录病毒D和马卡因疱疹病毒具有血清反应性。1骨髓评估显示，在高细胞骨髓中缺乏巨核细胞前体，并伴有明显的红系增生。根据这些发现，诊断为获得性巨核细胞性血小板减少性紫癜。由于该综合征的预后不良和猴子的临床恶化，因此选择了安乐死。尚未确定血小板减少的确切原因;然而，该综合征可能是由于最近的自然流产所致。据我们所知，该病例代表了恒河猴首次获得性巨核细胞性血小板减少性紫癜的报道。

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