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首页> 外文期刊>Comparative Medicine >Alternative Activation of Macrophages in Rhesus Macaques (Macaca mulatta) with Endometriosis
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Alternative Activation of Macrophages in Rhesus Macaques (Macaca mulatta) with Endometriosis

机译：内膜异位症对恒河猴（Macaca mulatta）中巨噬细胞的选择性激活

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Endometriosis is one cif the most frequently encountered gynecologic diseases and a common cause of chronic pelvic pain and infertility. The pathophysiology of this syndrome can best be described as the presence of ectopic endometrium and a pelvic inflammatory process with associated immune dysfunction and alteration in the peritoneal environment. Macrophages play an important role in the progression and propagation of endometriosis. Alternative macrophage activation occurs in rodents and women with endometriosis but had not been examined previously in nonhuman primates. This case control study aimed to characterize macrophage polarization in the ectopic and eutopic endometrial tissue of nonhuman primates with and without endometriosis. In addition, circulating cytokines in endometriosis cases and normal controls were investigated in an effort to identify serum factors that contribute to or result from macrophage polarization. Endometriosis lesions demonstrated increased infiltration by macrophages polarized toward the M2 phenotype when compared with healthy control endometrium. No serum cytokine trends consistent with alternative macrophage activation were identified. However, serum transforming growth factor alpha was elevated in macaques with endometriosis compared with healthy controls. Findings indicated that the activation state of macrophages in endometriosis tissue in nonhuman primates is weighted toward the M2 phenotype. This important finding enables rhesus macaques to serve as an animal model to investigate the contribution of macrophage polarization to the pathophysiology of endometriosis.
机译：子宫内膜异位症是最常见的妇科疾病之一，也是导致慢性盆腔疼痛和不育的常见原因。该综合征的病理生理学可以最好地描述为异位子宫内膜的存在和盆腔炎，并伴有相关的免疫功能障碍和腹膜环境的改变。巨噬细胞在子宫内膜异位症的发展和传播中起重要作用。啮齿动物和子宫内膜异位症妇女发生巨噬细胞的替代激活，但以前尚未在非人类灵长类动物中进行过检查。本病例对照研究旨在表征具有和不具有子宫内膜异位症的非人类灵长类动物的异位和异位子宫内膜组织中的巨噬细胞极化特征。此外，对子宫内膜异位症病例和正常对照中的循环细胞因子进行了研究，以鉴定有助于巨噬细胞极化或由巨噬细胞极化引起的血清因子。与健康对照组子宫内膜相比，子宫内膜异位病灶表现出向M2表型极化的巨噬细胞浸润增加。没有发现与替代性巨噬细胞激活相一致的血清细胞因子趋势。但是，与健康对照组相比，患有子宫内膜异位的猕猴血清转化生长因子α升高。结果表明，非人灵长类动物子宫内膜异位症组织中巨噬细胞的激活状态偏向于M2表型。这一重要发现使恒河猴能够作为动物模型来研究巨噬细胞极化对子宫内膜异位症病理生理的影响。

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