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首页> 外文期刊>Comparative Medicine >Cutaneous B-cell lymphoma in a Perdido Key beach mouse (Peromyscus poliontus trissyllepsis).
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Cutaneous B-cell lymphoma in a Perdido Key beach mouse (Peromyscus poliontus trissyllepsis).

机译：Perdido Key海滩老鼠（ Peromyscus poliontus trissyllepsis ）的皮肤B细胞淋巴瘤。

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The Perdido Key beach mouse (Peromyscus poliontus trissyllepsis) is an endangered mammal indigenous to the panhandle beaches of Northwest Florida. A captive 3.5-y-old female mouse was evaluated because of severe pruritus, diffuse alopecia, skin reddening, and ulcerations over the dorsum of her body. Initial skin biopsy of the affected area suggested bacterial dermatitis but was inconclusive. Despite empiric antibiotic, anthelmintic, and antihistamine treatments, she continued to decline and developed severe ulcerations over the majority of her body. Postmortem histopathologic evaluation led to a tentative diagnosis of epitheliotropic lymphoma, suggestive of a mycosis fungoides T-cell-type cutaneous lymphoma. However, immunohistochemistry results challenged this diagnosis, indicating that the lesion was actually an epidermotropic B-cell lymphoma. Spontaneous cutaneous B-cell lymphomas are rare in rodents and had not previously been reported to occur in Perdido Key beach mice. This case report provides initial evidence that the Perdido Key beach mouse is susceptible to cutaneous B-cell lymphoma.
机译：Perdido Key沙滩鼠（ Peromyscus poliontus trissyllepsis ）是西北佛罗里达泛指海滩上的一种濒临灭绝的哺乳动物。对一只圈养的3.5岁雌性小鼠进行了评估，原因是严重的瘙痒，弥漫性脱发，皮肤变红和身体背部出现溃疡。患处的初步皮肤活检提示细菌性皮炎，但尚无定论。尽管使用了经验性的抗生素，驱虫药和抗组胺药治疗，但她的身体大部分部位仍继续下降并出现严重溃疡。事后组织病理学评估导致对上皮性淋巴瘤的初步诊断，提示真菌病性真菌性T细胞型皮肤淋巴瘤。然而，免疫组织化学结果挑战了这一诊断，表明该病变实际上是表皮性B细胞淋巴瘤。自发性皮肤B细胞淋巴瘤在啮齿动物中很少见，以前没有报道在Perdido Key海滩小鼠中发生。该病例报告提供了Perdido Key beach小鼠易患皮肤B细胞淋巴瘤的初步证据。

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