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Comparative pathology of mouse models of human cancers

机译:人类癌症小鼠模型的比较病理学

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These are the first of a series of epitomes developed by the lead pathologists from the Mouse Models of Human Cancers Consortium (MMHCC) of the National Cancer Institute (NCI). Each epitome is designed to provide the reader with a short, but authoritative review of the pathologic features in each of 10 organ systems, with short bibliographies to lead the interested to the pertinent literature. The MMHCC is a program developed by the NCI, the mission of which is to assist in development, study, andvalidation of mouse models of human cancers. The MMHCC involves 40 institutions, and is currently organized into eight organ site committees and a number of standing committees. The organ committees include breast, ovary, prostate, gastrointestinal tract, lung, hematopoietic, neural, and skin. The MMHCC Steering Committee appointed a Standing Committee for Pathology and Laboratory Medicine that was charged with the tasks of "validating" the models and developing diagnostic nomenclature, annotated images, diagnostic characteristics, and technical protocols. These tasks were, in part, organized and performed during a series of workshops that were organized by the MMHCC organ site committees to evaluate the current status of animal models for their organsystems. Each meeting convened a workshop of MMHCC pathologists and outside experts, to examine and discuss slide sets representing models of the organ site. A consensus report has now been published describing the coonclusions of each workshop. With several exceptions, these epitomes are provided by the lead pathologist and organizer of the workshops.
机译:这些是由美国国家癌症研究所(NCI)的人类癌症协会小鼠模型(MMHCC)的首席病理学家开发的一系列缩影中的第一个。每个缩影旨在为读者提供10个器官系统中每个病理特征的简短但权威的综述,并附有简短的书目以使感兴趣的读者了解相关文献。 MMHCC是由NCI开发的程序,其任务是协助开发,研究和验证人类癌症小鼠模型。 MMHCC涉及40个机构,目前组织为八个器官部位委员会和多个常务委员会。器官委员会包括乳房,卵巢,前列腺,胃肠道,肺,造血,神经和皮肤。 MMHCC指导委员会任命了病理学和检验医学常务委员会,负责“验证”模型并开发诊断术语,带注释的图像,诊断特征和技术协议。这些任务部分是在MMHCC器官部位委员会组织的一系列研讨会中组织和执行的,以评估其器官系统动物模型的当前状态。每次会议都召开了MMHCC病理学家和外部专家的研讨会,以检查和讨论代表器官部位模型的幻灯片组。现在已经发布了共识报告,描述了每个研讨会的共同点。除了几个例外,这些缩影由研讨会的首席病理学家和组织者提供。

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